Analgesic and Anti-Inflammatory Activity of Sophora Mollis (Leguminosae) Leaves and Stem Extracts in Mice

Sophora mollis (Leguminosae) is used as traditional medicine against skin diseases, rheumatism and as anthelmintic in Nepal and other regions of Asia. Its analgesic and anti-inflammatory potential was not yet examined. The aim of this study was therefore to evaluate antinociceptive and anti-inflammatory activities of this plant in mice models. Methanolic and ethyl acetate extracts of stem and leaves were evaluated separately at the doses of 200 and 500mg/kg in comparison with standard reference of aspirin (300mg/kg). Analgesic potential was examined via hot-plate test and acetic acid induced writhing while anti-inflammatory effects were evaluated in formalin induced inflammation model. Extracts showed significant antinociceptive potential particularly methanolic extract of stem showed dose dependant analgesia comparable to high dose of aspirin. Anti-inflammatory effects were significant in both phases of inflammation and were in comparison with aspirin and codeine sulphate. Preliminary phytochemical screening revealed strong presence of saponins, tannins and alkaloids.