MANIA AFTER TRAUMATIC BRAIN INJURY - A REPORT OF 2 CASES AND 194 LITERATURE-REVIEW

Brain injuries, are according to the literature an infrequent cause of secondary mania. We present, two clinical case reports with maniform symptomatology, both preceded by a brain injury. In both cases, neuroimage techniques, showed brain posttraumatic damage (subcortical atrophy bifrontal injury in the first case and subcortical atrophy associated with a small subdural hematoma in the second case) that, in previous studies have been related with the presence of posttraumatic mania. None, of our two cases, had previous personal or familial antecedents of affective disorder. We shortly review the literature, focussing on clinical, pathogenesis, associated factors, and therapeutical alternatives.