IMMUNOHISTOCHEMICAL LOCALIZATION OF THROMBOXANE RECEPTOR AND THROMBOXANE SYNTHASE IN RAT TESTIS

被引：10
|
作者：
TAKAHASHI, N [1 ]
TAKEUCHI, K [1 ]
ABE, T [1 ]
MURAKAMI, K [1 ]
YAMAGUCHI, M [1 ]
ABE, K [1 ]
机构：
[1] TOHOKU UNIV, SCH MED, DEPT PATHOL, AOBA KU, SENDAI, MIYAGI 98077, JAPAN
来源：
ENDOCRINOLOGY | 1995年 / 136卷 / 09期
关键词：
D O I：
10.1210/en.136.9.4143
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The cellular localization of thromboxane Az receptor (TXR) and thromboxane synthase (TXS) in rat testes was examined with an antibody against the carboxyl-terminal tail of rat TXR and anti-porcine lung TXS antibody. By light microscopy immunoreactivity for TXR was shown to be present in spermatids, whereas spermatogonia, spermatocytes, and spermatozoa lacked the immunoreactivity. Immunoelectron microscopic analysis revealed that immunostainable TXR was present in acrosomes of spermatids. In contrast, immunoreactivity for TXS was present in all stages of spermatogenic cells; spermatogonia, spermatocytes, spermatids, and spermatozoa. TX system may possibly contribute to the formation of acrosomes or have some unrecognized functions in an autocrine/paracrine fashion.
引用
收藏
页码：4143 / 4146
页数：4
相关论文
共 50 条
  • [21] Immunolocalization of rat thromboxane receptor in the kidney
    Takahashi, N
    Takeuchi, K
    Abe, T
    Sugawara, A
    Abe, K
    ENDOCRINOLOGY, 1996, 137 (11) : 5170 - 5173
  • [22] THE EXPRESSION OF THROMBOXANE-A2 SYNTHASE AND THROMBOXANE-A2 RECEPTOR GENE IN HUMAN UTERUS
    SWANSON, ML
    LEI, ZM
    SWANSON, PH
    RAO, CV
    NARUMIYA, S
    HIRATA, M
    BIOLOGY OF REPRODUCTION, 1992, 47 (01) : 105 - 117
  • [23] CORRECTION OF ISCHEMIC BRAIN ACIDOSIS WITH A NOVEL THROMBOXANE RECEPTOR ANTAGONIST COMBINED WITH A THROMBOXANE SYNTHASE INHIBITOR
    PETTIGREW, LC
    HAZLE, JD
    GUTIERREZ, G
    ANNALS OF NEUROLOGY, 1990, 28 (02) : 223 - 224
  • [24] Thromboxane and the thromboxane receptor in cardiovascular disease
    Smyth, Emer M.
    CLINICAL LIPIDOLOGY, 2010, 5 (02) : 209 - 219
  • [25] THE EFFECT OF THROMBOXANE RECEPTOR BLOCKADE VERSUS THROMBOXANE SYNTHASE INHIBITION ON CANINE ARTERIAL GRAFT PATENCY
    BECH, FR
    CRONENWETT, JL
    MCDANIEL, MD
    OGLETREE, ML
    FREEMAN, DH
    JOURNAL OF VASCULAR SURGERY, 1990, 12 (02) : 119 - 125
  • [26] Inhibition of prostaglandin D2 clearance in rat hepatocytes by the thromboxane receptor antagonists daltroban and ifetroban and the thromboxane synthase inhibitor furegrelate
    Pestel, S
    Nath, A
    Jungermann, K
    Schieferdecker, HL
    BIOCHEMICAL PHARMACOLOGY, 2003, 66 (04) : 643 - 652
  • [27] Cellular localization of thromboxane synthase in ovine spinal cord and hindbrain
    Husted, D
    Upshaw, J
    Gridley, KE
    Wood, CE
    BRAIN RESEARCH, 2003, 971 (01) : 107 - 115
  • [28] Design, synthesis and biological evaluation of a sulfonylcyanoguanidine as thromboxane A2 receptor antagonist and thromboxane synthase inhibitor
    Dogné, JM
    Wouters, J
    Rolin, S
    Michaux, C
    Pochet, L
    Durant, F
    Delarge, J
    Masereel, B
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2001, 53 (05) : 669 - 680
  • [29] ROLE OF PROAGGREGATORY AND ANTIAGGREGATORY PROSTAGLANDINS IN HEMOSTASIS - STUDIES WITH COMBINED THROMBOXANE SYNTHASE INHIBITION AND THROMBOXANE RECEPTOR ANTAGONISM
    GRESELE, P
    ARNOUT, J
    DECKMYN, H
    HUYBRECHTS, E
    PIETERS, G
    VERMYLEN, J
    JOURNAL OF CLINICAL INVESTIGATION, 1987, 80 (05): : 1435 - 1445
  • [30] Association of polymorphisms in thromboxane A2 receptor and thromboxane A synthase 1 with cerebral infarction in a Korean population
    Park, Sun Ah
    Park, Byung Lae
    Park, Jeong Ho
    Lee, Tae Kyeong
    Sung, Ki Bum
    Lee, You Kyoung
    Chang, Hun Soo
    Park, Choon-Sik
    Shin, Hyoung Doo
    BMB REPORTS, 2009, 42 (04) : 200 - 205
12345