IMMUNOHISTOCHEMICAL LOCALIZATION OF THROMBOXANE RECEPTOR AND THROMBOXANE SYNTHASE IN RAT TESTIS

被引：10
|
作者：
TAKAHASHI, N [1 ]
TAKEUCHI, K [1 ]
ABE, T [1 ]
MURAKAMI, K [1 ]
YAMAGUCHI, M [1 ]
ABE, K [1 ]
机构：
[1] TOHOKU UNIV, SCH MED, DEPT PATHOL, AOBA KU, SENDAI, MIYAGI 98077, JAPAN
来源：
ENDOCRINOLOGY | 1995年 / 136卷 / 09期
关键词：
D O I：
10.1210/en.136.9.4143
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The cellular localization of thromboxane Az receptor (TXR) and thromboxane synthase (TXS) in rat testes was examined with an antibody against the carboxyl-terminal tail of rat TXR and anti-porcine lung TXS antibody. By light microscopy immunoreactivity for TXR was shown to be present in spermatids, whereas spermatogonia, spermatocytes, and spermatozoa lacked the immunoreactivity. Immunoelectron microscopic analysis revealed that immunostainable TXR was present in acrosomes of spermatids. In contrast, immunoreactivity for TXS was present in all stages of spermatogenic cells; spermatogonia, spermatocytes, spermatids, and spermatozoa. TX system may possibly contribute to the formation of acrosomes or have some unrecognized functions in an autocrine/paracrine fashion.
引用
收藏
页码：4143 / 4146
页数：4
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