In Vivo Animal Models in Preclinical Evaluation of Anti-Inflammatory Activity- A Review

Inflammation is defined as the local response of living mammalian tissues to injury due to any agent. Inflammation involves 2 basic processes early inflammatory response later followed by healing. There are two types of inflammation, Acute and Chronic. Acute inflammation is of short duration and represents the early body reaction, resolves quickly and is usually followed by healing. Chronic inflammation is defined as prolonged process in which tissue destruction and inflammation occur at same time. The anti-inflammatory activity of new substances can be evaluated by using various pre clinical screening method. Here by use of various phlogestic agent like carragenan, brewer's yeast, dextran, egg albumin, kaolin, aerosil, croton oil, cotton wool inflammation is induced and the amount of decrease in its inducing characteristics is measured.