SYNTHESIS AND ANTI-HIV ACTIVITY OF VARIOUS 2'-SUBSTITUTED AND 3'-SUBSTITUTED 2',3'-DIDEOXYADENOSINES - A STRUCTURE ACTIVITY ANALYSIS

被引:177
|
作者
HERDEWIJN, P [1 ]
PAUWELS, R [1 ]
BABA, M [1 ]
BALZARINI, J [1 ]
DECLERCQ, E [1 ]
机构
[1] CATHOLIC UNIV LEUVEN, REGA INST MED RES, B-3000 LOUVAIN, BELGIUM
关键词
D O I
10.1021/jm00394a034
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:2131 / 2137
页数:7
相关论文
共 50 条
  • [41] Design, Synthesis, and Structure–Activity Relationships of Novel 1-(Substituted)-2-Methyl-3-(4-Oxo-2-Methylquinazolin-3(4H)-yl) Isothioureas for Their Anti-HIV and Antibacterial Activities
    V. Alagarsamy
    M. T. Sulthana
    K. Chitra
    V. Raja Solomon
    G. Saravanan
    Russian Journal of Bioorganic Chemistry, 2022, 48 : 548 - 556
  • [42] Synthesis and herbicidal activity of ethoxyethyl 2-cyano-3(substituted)pyridinemethylamino-3-(substituted)acrylates
    Liu, Yu-Xiu
    Li, Heng
    Zhao, Qi-Qi
    Wang, Qing-Min
    Huang, Run-Qiu
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2006, 26 (09) : 1232 - 1238
  • [43] Asymmetrically substituted myo-inositols.: XXXIX.: The synthesis of conjugate of 2′,3′-didehydro-3′-deoxythymidine with phosphatidylinositol:: A new nucleoside phospholipid with potential anti-HIV activity
    Shastina, NS
    Tuchnaya, OA
    Einisman, LI
    Kashiricheva, II
    Stepanov, AE
    Yurkevich, AM
    Shvets, VI
    RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2003, 29 (03) : 267 - 273
  • [44] Asymmetrically Substituted myo-Inositols. XXXIX. The Synthesis of Conjugate of 2',3'-Didehydro-3'-deoxythymidine with Phosphatidylinositol: A New Nucleoside Phospholipid with Potential Anti-HIV Activity
    N. S. Shastina
    O. A. Tuchnaya
    L. I. Einisman
    I. I. Kashiricheva
    A. E. Stepanov
    A. M. Yurkevich
    V. I. Shvets
    Russian Journal of Bioorganic Chemistry, 2003, 29 : 267 - 273
  • [45] SYNTHESIS AND TUBERCULOSTATIC ACTIVITY OF 3-SUBSTITUTED AND 5-SUBSTITUTED 2-ARYLFURANS
    OLEINIK, AF
    DOZOROVA, EN
    SOLOVYOVA, NP
    POLUKHINA, LM
    FILITIS, LN
    POLYAKOVA, ON
    PERSHIN, GN
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1983, 17 (08): : 928 - 931
  • [46] SYNTHESIS AND ANTI-HIV ACTIVITY OF CARBOCYCLIC 2',3'-DIDEHYDRO-2',3'-DIDEOXY 2,6-DISUBSTITUTED PURINE NUCLEOSIDES
    VINCE, R
    HUA, M
    JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (01) : 17 - 21
  • [47] Synthesis and acaricidal activity of novel 2-substituted-3-trifluoromethylquinoxalines
    Fukushima, Y
    Ishii, N
    Imai, T
    Usui, M
    Umetsu, NK
    NEW DISCOVERIES IN AGROCHEMICALS, 2005, 892 : 304 - 312
  • [48] Synthesis and herbicidal activity of 2-cyano-3-substituted-pyridinemethylaminoacrylates
    Wang, QM
    Sun, HK
    Cao, HY
    Cheng, MR
    Huang, RQ
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2003, 51 (17) : 5030 - 5035
  • [49] SYNTHESIS AND ANTIALDOSTERONE ACTIVITY OF SUBSTITUTED 2,3,3-TRIPHENYLPROPYLAMINES
    BLANK, B
    ZUCCARELLO, WA
    COHEN, SR
    FRISHMUTH, GJ
    SCARICACIOTTOLI, D
    JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (05) : 873 - +
  • [50] SYNTHESIS AND ANTI-HIV ACTIVITY OF SUGAR-FLUORINATED 4'-THIO-2',3'-DIDEOXYNUCLEOSIDES
    JEONG, LS
    NICKLAUS, MC
    MARQUEZ, VE
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 208 : 31 - MEDI