DIFFERENTIAL DEVELOPMENT OF ANGIOTENSIN-II RECEPTOR SUBTYPES IN THE RAT-BRAIN

被引：80
|
作者：
TSUTSUMI, K
SAAVEDRA, JM
机构：
[1] Section on Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD
来源：
ENDOCRINOLOGY | 1991年 / 128卷 / 01期
关键词：
D O I：
10.1210/endo-128-1-630
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Angiotensin II receptors in selected brain areas were characterized into two distinct subtypes by displacement with specific antagonists. The receptor subtypes had different developmental patterns. Type-1 receptors, selectively displaced by the specific angiotensin antagonist DuP-753, were predominant in adult (8-weeks-old) rats. Type-2 receptors were selectively displaced by CGP 42112 A and were expressed remarkably in young (2-weeks-old) rats.
引用
收藏
页码：630 / 632
页数：3
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