KINETIC AND MECHANISTIC STUDIES ON OXIDATION OF DONEPEZIL HYDRO CHLORIDE BY CHLORAMINE - T IN BASIC MEDIUM

Donepezil hydrochloride is United States Food and Drug Administration (USFDA) approved drug marketed under the trade name "Aricept" used for the treatment of mild to moderate alzheimer disease. The aim of the current investigation was Kinetic and mechanistic study of donepezil hydrochloride by sodium-N-chloro-p-tolunesulfonamide or chloramine-T (CAT) in NaOH medium was studied at 308 K. the reaction follows first order dependence on [CAT](0), fractional order dependence on [substrate](0), and [OH-] ion concentration. Variation of ionic strength and addition of toluene sulfonamide have no significant effect on the rate. The reaction was studied at five different temperatures; however, the thermodynamic parameters have been assessed from the Arrhenius plots. The stoichiometry of the reaction has been established to be 1:1 and oxidation product 2-(1-benzylpiperdin-4-yl) methyl)-5-6-dimethoxy 3H-inden-1-ol was predicted by Chromatographic and Spectroscopic analysis. The observed results were supported by probable mechanism and the related rate law has been deduced.