CARBAPENEM RESISTANCE PROFILE AMONGST ESCHERICHIA COLI AND KLEBSIELLA PNEUMONIAE IN A TERTIARY CARE HOSPITAL IN AHMEDNAGAR, MAHARASHTRA

被引:2
|
作者
Gunjal, Shraddha Prasad [1 ]
Gunjal, Prasad Niranjan [1 ]
Vanaparthi, Nagaraju [1 ]
Sudheer, Kher [1 ]
机构
[1] PDVVPFs Dr Vikhe Patil Med Coll & Hosp, Dept Microbiol, Vadgon Gupta, Ahmednagar, Maharashtra, India
来源
INTERNATIONAL JOURNAL OF MEDICAL RESEARCH & HEALTH SCIENCES | 2014年 / 3卷 / 02期
关键词
Imipenem; Meropenem; Carbapenem-resistant;
D O I
10.5958/j.2319-5886.3.2.086
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Introduction: Carbapenem-resistant Enterobacteriaceae (CRE), specially three species of the Enterobacteriaceae family, the Klebsiella, Enterobacter and Escherichia have developed resistance to a group of antibiotics called "Carbapenems", which are often used as the last line of treatment when other antibiotics are not effective in treating infections caused by them. Aim of the study: The present study was carried out to detect carbapenem resistance profile among Escherichia coli & Klebsiella pneumoniae. Materials & Methods: Cultures were obtained from consecutive specimens like urine, pus, sputum and blood collected from indoor as well as outdoor patients of our hospital. Specimens were processed for culture and identification according to standard techniques. Cultures yielding only Escherichia coli & Klebsiella pneumoniae were included in the study. Antimicrobial susceptibility testing was performed on Mueller-Hinton agar plates by the standard Kirby-Bauer disk diffusion method recommended by CLSI against imipenem and meropem. The diameters of zone of inhibition were recorded as sensitive, resistant or intermediate sensitive according to the CLSI criteria. Results & Observations: Total 206 isolates were surveyed. Urine & pus were the commonest specimens which isolated Escherichia coli & Klebsiella pneumoniae. 58.82% & 8.82% E. coli were resistant to meropenem & imipenem respectively. Similarly, 53.84% & 30.76% K. pneumoniae were resistant to meropenem & imipenem respectively. Conclusion: K. pneumoniae and E. coli are commonly encountered pathogens from clinical specimens and exhibit resistance to carbapenems. E. coli and K. pneumoniae isolates showed higher resistance to meropenem (58.82% and 53.84%, respectively) as compared to imipenem (8.82% and 30.76% respectively). K. pneumoniae shows greater resistance to carbapenems as compared to E. coli.
引用
收藏
页码:424 / 427
页数:4
相关论文
共 50 条
  • [41] Outcome of carbapenem resistant Klebsiella pneumoniae infection in tertiary care centre in India
    Warrier, A.
    Patil, P.
    Gupta, P.
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2014, 21 : 416 - 416
  • [42] Study of Antimicrobial Resistance Pattern of Escherichia Coli at a Tertiary Care Hospital
    Anturlikar, S.
    Trivedi, N. A.
    Bhatt, J. D.
    INDIAN JOURNAL OF PHARMACOLOGY, 2013, 45 : S134 - S134
  • [43] COMPARISON OF DIRECT HOSPITALIZATION COSTS AND LENGTH OF STAY IN CARBAPENEM RESISTANT VERSUS CARBAPENEM SENSITIVE KLEBSIELLA PNEUMONIAE INFECTIONS IN A TERTIARY CARE HOSPITAL
    Priyendu, A.
    Ahmed, Z.
    Varma, M.
    K, E., V
    Nagappa, A. N.
    VALUE IN HEALTH, 2015, 18 (07) : A581 - A581
  • [44] Correlation between antimicrobial consumption and the prevalence of carbapenem-resistant Escherichia coli and carbapenem-resistant Klebsiella pneumoniae at a university hospital in Thailand
    Prakobsrikul, Natsinee
    Malathum, Kumthorn
    Santanirand, Pitak
    Chumnumwat, Supatat
    Piebpien, Pongsathorn
    Montakantikul, Preecha
    JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2019, 44 (02) : 292 - 299
  • [45] Prevalence of extended spectrum beta lactamase producing Escherichia coli and Klebsiella pneumoniae urinary isolates in a tertiary care hospital in Kathmandu, Nepal
    Chander A.
    Shrestha C.D.
    BMC Research Notes, 6 (1)
  • [46] Surveillance of carbapenem-resistant Klebsiella pneumoniae and Escherichia coli in perianal swab samples
    Caliskan, Guel
    Eren, Hale
    Aslan, Funda
    Tezgec, Nergis
    Imer, Habibe
    Souleiman, Esma
    Tuzemen, Ulku
    Onal, Ugur
    Kazak, Esra
    Heper, Yasemin
    Yilmaz, Emel
    Ozakin, Cuneyt
    Akalin, Halis
    INFECTION CONTROL & HOSPITAL EPIDEMIOLOGY, 2024, 45 (08) : 994 - 997
  • [47] Occurrence of Plasmid-Mediated AmpC β-Lactamases Among Escherichia coli and Klebsiella pneumoniae Clinical Isolates in a Tertiary Care Hospital in Bangalore
    Sasirekha, B.
    Shivakumar, Srividya
    INDIAN JOURNAL OF MICROBIOLOGY, 2012, 52 (02) : 174 - 179
  • [48] Occurrence of Plasmid-Mediated AmpC β-Lactamases Among Escherichia coli and Klebsiella pneumoniae Clinical Isolates in a Tertiary Care Hospital in Bangalore
    B. Sasirekha
    Srividya Shivakumar
    Indian Journal of Microbiology, 2012, 52 : 174 - 179
  • [49] Efficacy of ceftazidime/avibactam and plazomicin on carbapenem-resistant Klebsiella pneumoniae and Escherichia coli
    Oztas, Sevil
    Er, Doganhan Kadir
    Dundar, Devrim
    Keceli, Sema Askin
    ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA, 2024, 71 (02) : 110 - 120
  • [50] PREVALENCE OF PLASMID-MEDIATED AMPC beta-LACTAMASES IN ESCHERICHIA COLI AND KLEBSIELLA PNEUMONIAE AT TERTIARY CARE HOSPITAL OF ISLAMABAD, PAKISTAN
    Shafiq, Muhammad
    Rahman, Hazir
    Qasim, Muhammad
    Ayub, Najma
    Hussain, Shagufta
    Khan, Jafar
    Naeem, Madiha
    EUROPEAN JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY, 2013, 3 (04): : 267 - 271