SYNTHESIS OF N-[N-L-GAMMA-GLUTAMYL-L-CYSTEINYL-(CARBONYL-C-14)]-GLYCINE (GLUTATHIONE-C-14) AND OF [CYS-(CO)C-14]-(5S,6R)-LTC4

被引：3

作者：

PARENT, P

LEBORGNE, F

LELLOUCHE, JP

BEAUCOURT, JP

VANHOVE, A

机构：

[1] Service Des Molécules Marquées, Centre D'etudes Nucléaires de Saclay, Gif-Sur-Yvette, 91191

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1990年 / 28卷 / 06期

关键词：

D O I：

10.1002/jlcr.2580280603

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

[Cys‐14CO]‐glutathione or N‐[N‐L‐γ‐glutamyl‐L‐cysteinyl‐14CO] glycine was prepared by chemical synthesis, with the L,L‐natural configuration and a radiochemical yield of 1% based on sodium [14C] cyanide. This labelled compound was used to obtain [Cys‐14CO] with a yield of 15%. [Cys‐14CO]‐glutathione and [Cys‐14CO]LTC4 had a specific activity of 50 mCi/mmol (1.85 GBq/mmol). Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：633 / 644

页数：12

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