SYNTHESIS OF N-[N-L-GAMMA-GLUTAMYL-L-CYSTEINYL-(CARBONYL-C-14)]-GLYCINE (GLUTATHIONE-C-14) AND OF [CYS-(CO)C-14]-(5S,6R)-LTC4

[Cys‐14CO]‐glutathione or N‐[N‐L‐γ‐glutamyl‐L‐cysteinyl‐14CO] glycine was prepared by chemical synthesis, with the L,L‐natural configuration and a radiochemical yield of 1% based on sodium [14C] cyanide. This labelled compound was used to obtain [Cys‐14CO] with a yield of 15%. [Cys‐14CO]‐glutathione and [Cys‐14CO]LTC4 had a specific activity of 50 mCi/mmol (1.85 GBq/mmol). Copyright © 1990 John Wiley & Sons, Ltd.