NOVEL ANTITUMOR ANTIBIOTICS, SAPTOMYCINS .1. TAXONOMY OF THE PRODUCING ORGANISM, FERMENTATION, HPLC ANALYSIS AND BIOLOGICAL-ACTIVITIES

被引：21

作者：

ABE, N

NAKAKITA, Y

NAKAMURA, T

ENOKI, N

UCHIDA, H

MUNEKATA, M

机构：

[1] Pharmaceutical Research Laboratories, Sapporo Breweries, Ltd., Shizuoka 425, 10 Okatohme, Yaizu

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 10期

关键词：

D O I：

10.7164/antibiotics.46.1530

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Streptomyces sp. HP530 was found to produce novel antitumor antibiotics, saptomycins, closely related to the pluramycin-group and was further found to mutate frequently. The natural mutant produced several new saptomycins as determined by HPLC analyses. We isolated saptomycins A, B, C1, C2 and F from the parent strain and saptomycins D, E, G and H from the mutant. The saptomycins showed antimicrobial activities and potent antitumor activities against human or murine tumor cell lines in vitro and against Meth A fibrosarcoma in vivo. In particular, saptomycin D was most effective component in vivo of all saptomycins.

引用

页码：1530 / 1535

页数：6

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