The c-fos proto-oncogene encodes a nuclear phosphoprotein, Fos which has been proposed to be a ''third messenger'' coupling short term extracellular signals to long term alteration in cell function. Using double labeling immunocytochemistry, the present work demonstrated the co-localization of Fos protein and serotonin in the nucleus raphe dorsalis, nucleus raphe centralis superior and rostral ventromedial medulla. The results pose an interesting problem, the possible relation of Fos protein to the biosynthesis of serotonin, awaiting further investigation.
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Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Hershey, PA 17033 USAPenn State Univ, Milton S Hershey Med Ctr, Coll Med, Hershey, PA 17033 USA
Wrzos, HF
Guillaume, M
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Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Hershey, PA 17033 USAPenn State Univ, Milton S Hershey Med Ctr, Coll Med, Hershey, PA 17033 USA
Guillaume, M
Norgren, R
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Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Hershey, PA 17033 USAPenn State Univ, Milton S Hershey Med Ctr, Coll Med, Hershey, PA 17033 USA
Norgren, R
Smith, K
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Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Hershey, PA 17033 USAPenn State Univ, Milton S Hershey Med Ctr, Coll Med, Hershey, PA 17033 USA
Smith, K
Evey, LA
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Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Hershey, PA 17033 USAPenn State Univ, Milton S Hershey Med Ctr, Coll Med, Hershey, PA 17033 USA
Evey, LA
Ouyang, A
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Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Hershey, PA 17033 USAPenn State Univ, Milton S Hershey Med Ctr, Coll Med, Hershey, PA 17033 USA