SEROTONIN MODULATES MUSCIMOL-ELICITED AND BACLOFEN-ELICITED INHIBITION OF CEREBELLAR PURKINJE-CELLS

被引：23
|
作者：
STRAHLENDORF, JC
LEE, MH
STRAHLENDORF, HK
机构：
[1] Department of Physiology, Texas Tech University Health Sciences Center, Lubbock, TX 79430
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 201卷 / 2-3期
关键词：
5-HT; (5-HYDROXYTRYPTAMINE; SEROTONIN); MUSCIMOL; BACLOFEN; CEREBELLUM; PURKINJE CELLS;
D O I：
10.1016/0014-2999(91)90352-Q
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The present study was designed to test whether serotonin (5-HT) preferentially affects the GABA(A) or GABA(B) receptor subtypes in the cerebellum using muscimol and baclofen as the selective agonists. Serotonin significantly augmented baclofen- and muscimol-elicited inhibitions with minimal effects of 5-HT on the spontaneous activity. The magnitudes of augmentation of baclofen and muscimol effects seen in the presence of 5-HT were comparable. In summary, this study further describes the neuromodulatory role of serotonin on GABAergic inhibition and based upon the present study, it can be concluded that both GABA(A) and GABA(B) receptor subtypes are modulated by 5-HT.
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页码：239 / 242
页数：4
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