INCOMPLETE REVERSAL OF ENOXAPARIN-INDUCED BLEEDING BY PROTAMINE SULFATE

被引：0
|
作者：
BANG, CJ [1 ]
BERSTAD, A [1 ]
TALSTAD, I [1 ]
机构：
[1] HAUKELAND UNIV HOSP,DEPT MED,DIV HAEMATOL,N-5021 BERGEN,NORWAY
来源：
HAEMOSTASIS | 1991年 / 21卷 / 03期
关键词：
ENOXAPARIN; PROTAMINE SULFATE; PRIMARY HEMOSTASIS; BLEEDING MODELS;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The neutralizing effect of protamine sulfate on enoxaparin-induced bleeding was compared in two rat models: one employing the gastric mucosa, and the other the tail skin, using a 2:1 ratio of protamine sulfate to enoxaparin on a weight basis. Whereas protamine sulfate reduced the median bleeding time (from 20 to 9.5 min) and blood loss (80%) in the gastric mucosa, an apparent 'all-or-none' response was seen in the tail skin, in agreement with a different hemostatic mechanism in the two bleeding models. In both models, protamine sulfate incompletely reversed the bleeding induced by enoxaparin.
引用
收藏
页码：155 / 160
页数：6
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