UNIPARENTAL ORIGIN OF SEX-CHROMOSOME POLYSOMIES

被引：18
|
作者：
LORDASANCHEZ, I
BINKERT, F
HINKEL, KG
MOSER, H
ROSENKRANZ, W
MAECHLER, M
SCHINZEL, A
机构：
[1] UNIV ZURICH,INST MED GENET,RAMISTR 74,CH-8001 ZURICH,SWITZERLAND
[2] MED ACAD CARL GUSTAV CARUS,DIV CLIN GENET,DRESDEN,GERMANY
[3] UNIV BERN,DEPT PEDIAT,DIV MED GENET,CH-3000 BERN,SWITZERLAND
[4] GRAZ UNIV,INST MED BIOL & HUMAN GENET,A-8010 GRAZ,AUSTRIA
来源：
HUMAN HEREDITY | 1992年 / 42卷 / 03期
关键词：
SEX CHROMOSOME POLYSOMY; PARENTAL ORIGINS; NONDISJUNCTION;
D O I：
10.1159/000154066
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The parental origin of the additional sex chromosomes in 8 cases with high-order sex chromosome polysomies was determined using DNA polymorphisms. The additional sex chromosomes were paternally derived in 3 48,XXYY cases, and maternal in origin in 1 48,XXXY case and 4 49,XXXXY cases. Thus, all extra chromosomes, within a particular patient, were always derived from only one parent. Their most likely origin was successive nondisjunction at the first and second meiotic division in one germ cell. The mechanism involved remains unclear, but appears to be independent of parental ages.
引用
收藏
页码：193 / 197
页数：5
相关论文
共 50 条
  • [31] SEX-CHROMOSOME ABNORMALITY IN A PATIENT WITH TRANSSEXUALISM
    JAMES, S
    DAVIES, DW
    ORWIN, A
    BRITISH MEDICAL JOURNAL, 1972, 2 (5817): : 29 - &
  • [32] DEVELOPMENT OF CHILDREN WITH SEX-CHROMOSOME ABNORMALITIES
    RATCLIFFE, SG
    PROCEEDINGS OF THE ROYAL SOCIETY OF MEDICINE-LONDON, 1976, 69 (03): : 189 - 191
  • [33] NEONATAL DEATHS AND SEX-CHROMOSOME ANOMALIES
    ROBINSON, A
    LANCET, 1974, 1 (7868): : 1223 - 1223
  • [34] A sex-chromosome mutation in Silene latifolia
    Paige M. Miller
    Richard V. Kesseli
    Sexual Plant Reproduction, 2011, 24 : 211 - 217
  • [35] SEX-CHROMOSOME AND CHROMATIN EXAMINATION IN GYNECOLOGY
    QINSHENG, G
    LIYU, H
    MINYI, T
    YIWEN, Z
    HUOSHUN, T
    JINXIA, L
    XIENTING, Z
    CHINESE MEDICAL JOURNAL, 1979, 92 (05) : 310 - 320
  • [36] FEMALE WITH XXXX SEX-CHROMOSOME COMPLEMENT
    RERRICK, EG
    JOURNAL OF MENTAL DEFICIENCY RESEARCH, 1972, 16 (JUN): : 84 - 89
  • [37] SEX-CHROMOSOME ABNORMALITIES AND NOONAN SYNDROME
    NIELSEN, DB
    ARIZONA MEDICINE, 1980, 37 (07) : 486 - 490
  • [38] SEX-CHROMOSOME ANOMALIES, HORMONES AND SEXUALITY
    SCHIAVI, RC
    THEILGAARD, A
    OWEN, D
    WHITE, D
    PSYCHOSOMATIC MEDICINE, 1987, 49 (02): : 212 - 212
  • [39] A sex-chromosome mutation in Silene latifolia
    Miller, Paige M.
    Kesseli, Richard V.
    SEXUAL PLANT REPRODUCTION, 2011, 24 (03): : 211 - 217
  • [40] SEX-CHROMOSOME ANOMALIES, HORMONES, AND SEXUALITY
    SCHIAVI, RC
    THEILGAARD, A
    OWEN, DR
    WHITE, D
    ARCHIVES OF GENERAL PSYCHIATRY, 1988, 45 (01) : 19 - 24
12345