Two-photon absorption coefficients in Hg0.78Cd0.22Te are calculated for 10.6-mu-m radiation at 150 and 300 K by using the Basov formula and the nonparabolic energy band structure approximation. The temperature and composition dependence of the energy gap of HgCdTe are included in these calculations. Good agreement is obtained with the available experimental data. Predictions are made for the two-photon absorption coefficients at 40 and 77 K.