PREPARATION OF WATER-SOLUBLE HYDRONAPHTHOQUINONE DERIVATIVES AND ITS APPLICATION TO THE DETERMINATION OF HYDROGEN-PEROXIDE IN CLINICAL-CHEMISTRY

被引：1

作者：

OHTA, S ^{[1
]}

HATAKEYAMA, S ^{[1
]}

AONO, C ^{[1
]}

KOIKE, T ^{[1
]}

TANIMIZU, I ^{[1
]}

HIRAKAWA, H ^{[1
]}

机构：

[1] NIPPONSHOJI LTD, DIAGNOST RES LAB, IBARAKI 567, JAPAN

来源：

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 1992年 / 112卷 / 08期

关键词：

HYDROGEN PEROXIDE; 1,3-DICHLORONAPHTHOQUINONE; 1,3-DICHLOROHYDRONAPHTHOQUINONE; CLINICAL CHEMISTRY; PEROXIDASE; COLORIMETRIC DETERMINATION; SERUM CHOLESTEROL;

D O I：

10.1248/yakushi1947.112.8_585

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Several 1-alkoxy-2,3-dichloro-4-hydroxynaphthalene derivatives were prepared. These compounds were oxidized by hydrogen peroxide in the presence of a peroxidase to give 2,3-dichloro-1,4-naphthoquinone, which then reacted with various alkyl benzoylacetates to develop blue coloration with absorption maximum at > 600 nm. The color development reaction can be applied to the determination of appropriate serum constituents such as cholesterol.

引用

页码：585 / 591

页数：7

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