ANALYSIS OF BINARY DATA FROM A MULTICENTER CLINICAL-TRIAL

被引：4
|
作者：
RAGHUNATHAN, TE
II, YC
机构：
来源：
BIOMETRIKA | 1993年 / 80卷 / 01期
关键词：
CATEGORICAL DATA; CONDITIONAL LIKELIHOOD; EM-ALGORITHM; EMPIRICAL BAYES; MIXED MODEL;
D O I：
10.2307/2336763
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We develop several methods for estimating the treatment effect difference defined as the overall log-odds ratio of favourable response in a multicentre clinical trial comparing two treatments with binary response. A simulation study compares the bias and mean squared error of the point estimates and the exact coverage probabilities of confidence intervals obtained distributions.
引用
收藏
页码：127 / 139
页数：13
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