ANALYSIS OF BINARY DATA FROM A MULTICENTER CLINICAL-TRIAL

被引：4
|
作者：
RAGHUNATHAN, TE
II, YC
机构：
来源：
BIOMETRIKA | 1993年 / 80卷 / 01期
关键词：
CATEGORICAL DATA; CONDITIONAL LIKELIHOOD; EM-ALGORITHM; EMPIRICAL BAYES; MIXED MODEL;
D O I：
10.2307/2336763
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We develop several methods for estimating the treatment effect difference defined as the overall log-odds ratio of favourable response in a multicentre clinical trial comparing two treatments with binary response. A simulation study compares the bias and mean squared error of the point estimates and the exact coverage probabilities of confidence intervals obtained distributions.
引用
收藏
页码：127 / 139
页数：13
相关论文
共 50 条
  • [1] A BAYESIAN-ANALYSIS OF BIVARIATE SURVIVAL-DATA FROM A MULTICENTER CANCER CLINICAL-TRIAL
    GUSTAFSON, P
    STATISTICS IN MEDICINE, 1995, 14 (23) : 2523 - 2535
  • [2] AN EVALUATION OF THE DATA VALIDATION SYSTEM IN A MULTICENTER CLINICAL-TRIAL
    JACKSON, MR
    WILLIAMS, OD
    HOSKING, JD
    SCOTT, PP
    SMITH, C
    PARKER, R
    CONTROLLED CLINICAL TRIALS, 1984, 5 (03): : 312 - 312
  • [3] USE OF A VIEWDATA SYSTEM TO COLLECT DATA FROM A MULTICENTER CLINICAL-TRIAL IN ANESTHESIA
    WALDRON, HA
    COOKSON, RF
    BRITISH MEDICAL JOURNAL, 1984, 289 (6451): : 1059 - 1061
  • [4] MANAGEMENT OF A MULTICENTER CLINICAL-TRIAL
    CHAN, YK
    ARCHIBALD, DD
    PEDUZZI, PN
    TRENDS IN PHARMACOLOGICAL SCIENCES, 1983, 4 (01) : 21 - 24
  • [5] USE OF AND SATISFACTION WITH A DISTRIBUTED DATA SYSTEM IN A MULTICENTER CLINICAL-TRIAL
    BENNER, S
    BAGNIEWSKA, A
    BLACK, D
    CURTIS, C
    HULLEY, SB
    CONTROLLED CLINICAL TRIALS, 1983, 4 (02): : 157 - 158
  • [6] ANALYSIS OF INCOMPLETE DATA FROM A CLINICAL-TRIAL WITH REPEATED MEASUREMENTS
    PATEL, HI
    BIOMETRIKA, 1991, 78 (03) : 609 - 619
  • [7] THE EFFECTIVE USE OF A LOCAL AREA NETWORK FOR THE DATA MANAGEMENT OF CLINICAL AND NUTRITIONAL DATA FROM A MULTICENTER CLINICAL-TRIAL
    SAYRE, J
    ELASHOFF, R
    WANG, HJ
    LEE, JK
    CONTROLLED CLINICAL TRIALS, 1986, 7 (03): : 234 - 234
  • [8] TREATMENT OF HEMORRHOIDS - MULTICENTER CLINICAL-TRIAL
    CLYNE, MJ
    PRACTITIONER, 1977, 218 (1307) : 706 - 707
  • [9] COMPUTERS IN COORDINATION OF A MULTICENTER CLINICAL-TRIAL
    SEVERE, JB
    PSYCHOPHARMACOLOGY BULLETIN, 1987, 23 (02) : 261 - 263
  • [10] MULTICENTER CLINICAL-TRIAL OF EXTEROL AS A CERUMENOLYTIC
    FAHMY, S
    WHITEFIELD, M
    BRITISH JOURNAL OF CLINICAL PRACTICE, 1982, 36 (05): : 197 - 204
12345