The Future of Physiologically Based Pharmacokinetic Modeling to Predict Drug Exposure in Pregnant Women

被引：7
|
作者：
Vinks, A. A. [1 ,2 ]
机构：
[1] Cincinnati Childrens Hosp Med Ctr, Dept Clin Pharmacol, Cincinnati, OH 45229 USA
[2] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA
来源：
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY | 2013年 / 2卷 / 03期
关键词：
D O I：
10.1038/psp.2013.9
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Pregnant women have long been orphaned from drug studies. The application of physiologically based pharmacokinetic modeling to quantitatively describe drug disposition and effects during pregnancy is an attractive approach that is now actively pursued as it allows optimal use of available information for both efficient study designs and prediction of maternal-fetal exposure.
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页数：3
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