SITE-SPECIFIC FUNCTIONALIZATION OF PROTEINS AND THEIR APPLICATIONS TO THERAPEUTIC ANTIBODIES

被引：36

作者：

van Vught, Remko ^{[1
]}

Pieters, Roland J. ^{[2
]}

Breukink, Eefjan ^{[1
]}

机构：

[1] Univ Utrecht, Inst Biomembranes, Dept Membrane Biochem & Biophys, Padualaan 8, NL-3584 CH Utrecht, Netherlands

[2] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Med Chem & Chem Biol, NL-3508 TB Utrecht, Netherlands

来源：

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL | 2014年 / 9卷 / 14期

关键词：

D O I：

10.5936/csbj.201402001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein modifications are often required to study structure and function relationships. Instead of the random labeling of lysine residues, methods have been developed to (sequence) specific label proteins. Next to chemical modifications, tools to integrate new chemical groups for bioorthogonal reactions have been applied. Alternatively, proteins can also be selectively modified by enzymes. Herein we review the methods available for site-specific modification of proteins and their applications for therapeutic antibodies.

引用

页数：13

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