IDENTIFICATION OF NEW URINARY METABOLITES OF TRIMEPRAZINE IN RATS BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

被引：5
|
作者：
KIM, TJ [1 ]
PARK, JS [1 ]
SHIN, HS [1 ]
机构：
[1] DEUTSCHE SPORTHSCH KOLN,INST BIOCHEM,W-5000 COLOGNE,GERMANY
来源：
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 575卷 / 02期
关键词：
D O I：
10.1016/0378-4347(92)80160-R
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The metabolites of trimeprazine were identified in urine of rats by gas chromatography-mass spectrometry. After the oral administration of trimeprazine, the urinary metabolites were extracted with diethyl ether before or after hydrolysis with beta-glucuronidase. The identified metabolites were N-demethyltrimeprazine, 3-hydroxytrimeprazine, N-demethyl-3-hydroxytrimeprazine and trimeprazine sulphoxide.
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页码：295 / 300
页数：6
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