THYMINE TRANSPORT IN LACTOBACILLUS-CASEI

被引：0
|
作者：
AVRAHAM, Y
GROSSOWICZ, N
DEGROOT, N
YASHPHE, J
机构：
[1] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT BACTERIOL,IL-91010 JERUSALEM,ISRAEL
[2] HEBREW UNIV JERUSALEM,INST LIFE SCI,DEPT BIOL CHEM,JERUSALEM,ISRAEL
来源：
FEMS MICROBIOLOGY LETTERS | 1992年 / 94卷 / 1-2期
关键词：
THYMINE TRANSPORT; LACTOBACILLUS-CASEI;
D O I：
暂无
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A transport system for thymine was investigated in a Lactobacillus casei mutant lacking thymidine phosphorylase activity (the first enzyme required for thymine utilization). Transport was dependent on an energy supply; transport was inhibited by the uncouplers carbonylcyanide-m-chlorophenylhydrazone (CCCP) and 2,4 dinitrophenol (DNP), and also by sodium azide and N,N'-dicyclohexylcarbodiimide (DCCD). Thymine transport was inhibited by some uracil and adenosine derivatives and by thymidine, but was not affected by guanosine, deoxycytidine or azacytidine. Inhibition by p-chloromercurybenzoate (PCMB) was reversed by dithiothreitol (DTT).
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页码：43 / 46
页数：4
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