THYROTROPIN-RELEASING-HORMONE EXCITES SUBMUCOUS NEURONS IN GUINEA-PIG ILEUM

被引：9
|
作者：
ZAFIROV, DH [1 ]
COOKE, HJ [1 ]
WOOD, JD [1 ]
机构：
[1] OHIO STATE UNIV, COLL MED, DEPT PHYSIOL, 333 W 10TH AVE, COLUMBUS, OH 43210 USA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 204卷 / 01期
关键词：
ENTERIC NERVOUS SYSTEM; AUTONOMIC GANGLIA; ILEUM (GUINEA-PIG); THYROTROPIN-RELEASING HORMONE (TRH); INTESTINAL SECRETION; INTESTINAL MUCOSA; SYNAPTIC TRANSMISSION;
D O I：
10.1016/0014-2999(91)90843-F
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Actions of thyrotropin-releasing hormone (TRH) on submucous neurons of the guinea-pig ileum were examined with intracellular electrophysiological methods. TRH evoked excitatory responses in S/type 1 and AH/type 2 neurons. The responses consisted of slowly activating membrane depolarization, augmented excitability and an increase in input resistance that resulted from a decrease in potassium conductance. The results suggest a neuromodulatory/neurotransmitter function for TRH.
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页码：109 / 112
页数：4
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