EFFECT OF PLATELET-ACTIVATING-FACTOR ANTAGONIST ON BRAIN INJURY IN RATS

被引：0
|
作者：
TOKUTOMI, T
SIGEMORI, M
KIKUCHI, T
HIROHATA, M
机构：
来源：
ACTA NEUROCHIRURGICA | 1994年
关键词：
PAF ANTAGONIST; BRAIN ISCHEMIA; BRAIN EDEMA COLD INJURY;
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The ability of a platelet-activating factor (PAF) antagonist to reduce infarct size has been reported in a animal model of focal brain ischemia. The authors studied the effect of PAF antagonist (TCV-309) on cold brain injury in rats. Twenty-four hours after injury, water content was determined by both drying-weighing and spesific gravimetric techniques, and ischemic brain damage was assesed with 2,3,5-triphenyltetrazolium chloride in multiple coronal sections. Pretreatment with TCV-309 (lmg/kg) significantly reduced the water content (p < 0.01) and volume of ischemic damage (p < 0.001) produced by the cold brain injury. These results indicate that PAF antagonist can ameliorate secondary brain tissue damage following brain injury.
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页码：508 / 510
页数：3
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