LEUKEMIA DERIVED GROWTH-FACTORS PRODUCED BY HUMAN-MALIGNANT T-LYMPHOID CELL-LINES

被引：0

作者：

UITTENBOGAART, CH ^{[1
]}

NISHANIAN, PG ^{[1
]}

ANISMAN, DJ ^{[1
]}

ERIKSON, TKG ^{[1
]}

FAHEY, JL ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES, SCH MED, JONSSON COMPREHENS CANC CTR, LOS ANGELES, CA 90024 USA

来源：

CANCER RESEARCH | 1986年 / 46卷 / 03期

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An autocrine (noninterleukin 2) growth factor, which we term leukemia derived growth factor (LDGF), has previously been found in the culture supernatant of the human malignant T-lymphoid cell line MOLT-4f. We now show that two other human malignant T-lymphoid cell lines, CCRF-CEM and CCRF-HSB-2 also produce such a factor. All three factors, i.e., the LDGF from MOLT-4f, CCRF-CEM and CCRF-HSB-2 are similar to each other both in biological activity and in physicochemical characteristics. In addition to their autocrine activity, these LDGFs stimulate the growth of other malignant T-lymphoid cell lines, but they do not stimulate B-lymphoblastoid or myeloid cell lines. The results therefore suggest that these LDGFs are T-cell specific.

引用

页码：1219 / 1223

页数：5

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