ACETYLCHOLINE MODULATES THE EFFECT OF OVARIAN-STEROIDS ON GLUTAMIC-ACID DECARBOXYLASE ACTIVITY IN THE RAT FALLOPIAN-TUBE

被引：2
|
作者：
APUD, JA
MONASTEROLO, L
机构：
[1] UNIV BUENOS AIRES,FAC MED,DEPT FARMACOL & TOXICOL,BUENOS AIRES,ARGENTINA
[2] CONSEJO NACL INVEST CIENT & TECN,INST INVEST FARMACOL,BUENOS AIRES,ARGENTINA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 205卷 / 03期
关键词：
ALPHA-AMINOBUTYRIC ACID; GLUTAMIC ACID DECARBOXYLASE; ACETYLCHOLINE; OVIDUCT (RAT); SEXUAL STEROIDS;
D O I：
10.1016/0014-2999(91)90917-F
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Glutamic acid decarboxylase (GAD) activity was measured in the oviduct of normal rats in diestrous and in rats ovariectomized (OVX) seven days before. OVX induced a significant decrease of GAD activity in the Fallopian tube. This effect was completely reversed by coadministration of estradiol benzoate + progesterone (E + P). Simultaneous injection of atropine, but not of alpha-methyl-para-tyrosine or labetalol, completely prevented the activation of GAD induced by ovarian sterois. Moreover, prostigmin significantly potentiated the action of E + P on GAD activity in the rat oviduct. These data clearly suggest the participation of acetylcholine in the mecanisms whereby ovarian steroids regulate GAD activity in the rat Fallopian tube.
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页码：315 / 317
页数：3
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