The inverse association between eGFR and depression in patients with coronary artery disease: A cross-sectional study

Background The relationship between estimated glomerular filtration rate(e GFR) and depression in patients with coronary artery disease(CAD) remained unclear. Methods A total of 561 patients with CAD were selected from Department of Cardiology between October 2017 and February 2018 while their depression status was evaluated by Patient Health Questionnaire-9(PHQ-9). The e GFR levels were compared between patients with and without depression and the link between e GFR and depression in CAD patients was explored. Results Among 561CAD patients, 63 patients(11.23%) were diagnosed with comorbid depression(PHQ-9 ≥10). The depression group presented significantly lower e GFR level than the non-depression group. In fully-adjusted multivariate analysis,higher e GFR level was proved to be a protective factor for depression in CAD patients, reducing a 22% risk of depression for every 10 m L/(min · 1.73 m2) increase of e GFR level(OR: 0.78, 95% CI: 0.66-0.93). Similar results were found in the stratified analyses of both e GFR quartiles and chronic kidney disease(CKD) stages(P for trend <0.05), while no significant differences were found among subgroups(P for interaction >0.05). A negative linear association was estimated between e GFR level and depression in CAD patients. Conclusions Our results suggested lower e GFR level in CAD patients with comorbid depression, displaying a negative linear correlation between e GFR and risk of depression in CAD patients. The findings implied that screening depression in CAD patients with decreased e GFR level or concomitant CKD should be highlighted in clinical practice.[S Chin J Cardiol 2024;25(1):1-10]