Cytotoxic rearranged angucycline glycosides from deep sea-derived Streptomyces lusitanus SCSIO LR32

被引：0

作者：

Xiangcheng Zhu

Yanwen Duan

Zhaomeng Cui

Zhen Wang

Zengxia Li

Yun Zhang

Jianhua Ju

Hongbo Huang

机构：

[1] Xiangya International Academy of Translational Medicine,Department of Biochemistry and Molecular Biology

[2] Central South University,undefined

[3] National Engineering Research Center of Combinatorial Biosynthesis for Drug Discovery,undefined

[4] Key Laboratory of Metabolism and Molecular Medicine,undefined

[5] the Ministry of Education,undefined

[6] School of Basic Medical Sciences,undefined

[7] Fudan University,undefined

[8] CAS Key Laboratory of Tropical Marine Bio-resources and Ecology,undefined

[9] Guangdong Key Laboratory of Marine Materia Medica,undefined

[10] South China Sea Institute of Oceanology,undefined

[11] Chinese Academy of Sciences,undefined

来源：

The Journal of Antibiotics | 2017年 / 70卷

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摘要：

Two new rearranged linear angucycline glycosides, designated grincamycins G and H (1 and 2), together with three known congers P-1894B (vineomycin A1, 3), saquayamycin B (4) and vineomycin B2 (5), were obtained from marine-derived actinomycete Streptomyces lusitanus SCSIO LR32. The structures of 1 and 2 were elucidated by MS, 1D and 2D NMR techniques. Compounds 2–5 showed significant inhibitory effect on Jurkat T-cell proliferation with IC50 values of 3.0, 0.011, 0.037 and 0.3 μM, respectively.

引用

页码：819 / 822

页数：3