Cytotoxic rearranged angucycline glycosides from deep sea-derived Streptomyces lusitanus SCSIO LR32

被引：0

作者：

Xiangcheng Zhu

Yanwen Duan

Zhaomeng Cui

Zhen Wang

Zengxia Li

Yun Zhang

Jianhua Ju

Hongbo Huang

机构：

[1] Xiangya International Academy of Translational Medicine,Department of Biochemistry and Molecular Biology

[2] Central South University,undefined

[3] National Engineering Research Center of Combinatorial Biosynthesis for Drug Discovery,undefined

[4] Key Laboratory of Metabolism and Molecular Medicine,undefined

[5] the Ministry of Education,undefined

[6] School of Basic Medical Sciences,undefined

[7] Fudan University,undefined

[8] CAS Key Laboratory of Tropical Marine Bio-resources and Ecology,undefined

[9] Guangdong Key Laboratory of Marine Materia Medica,undefined

[10] South China Sea Institute of Oceanology,undefined

[11] Chinese Academy of Sciences,undefined

来源：

The Journal of Antibiotics | 2017年 / 70卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Two new rearranged linear angucycline glycosides, designated grincamycins G and H (1 and 2), together with three known congers P-1894B (vineomycin A1, 3), saquayamycin B (4) and vineomycin B2 (5), were obtained from marine-derived actinomycete Streptomyces lusitanus SCSIO LR32. The structures of 1 and 2 were elucidated by MS, 1D and 2D NMR techniques. Compounds 2–5 showed significant inhibitory effect on Jurkat T-cell proliferation with IC50 values of 3.0, 0.011, 0.037 and 0.3 μM, respectively.

引用

页码：819 / 822

页数：3

共 41 条

[1] Cytotoxic rearranged angucycline glycosides from deep sea-derived Streptomyces lusitanus SCSIO LR32
Zhu, Xiangcheng
Duan, Yanwen
Cui, Zhaomeng
Wang, Zhen
Li, Zengxia
Zhang, Yun
Ju, Jianhua
Huang, Hongbo
JOURNAL OF ANTIBIOTICS, 2017, 70 (07): : 819 - 822
[2] Cytotoxic Angucycline Class Glycosides from the Deep Sea Actinomycete Streptomyces lusitanus SCSIO LR32
Huang, Hongbo
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Sun, Aijun
Ma, Junying
Wang, Bo
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Huang, Caiguo
Zhang, Changsheng
Ju, Jianhua
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[3] Grincamycins I-K, Cytotoxic Angucycline Glycosides Derived from Marine-Derived Actinomycete Streptomyces lusitanus SCSIO LR32
Lai, Zhenzhu
Yu, Jianchen
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[4] Cytotoxic and Antibacterial Marfuraquinocins from the Deep South China Sea-Derived Streptomyces niveus SCSIO 3406
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[5] Deciphering the Glycosylation Steps in the Biosynthesis of P-1894B and Grincamycin Isolated from Marine-Derived Streptomyces lusitanus SCSIO LR32
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[7] A new diketopiperazine derivative from a deep sea-derived Streptomyces sp SCSIO 04496
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[8] Cytotoxic and Antibacterial Angucycline- and Prodigiosin- Analogues from the Deep-Sea Derived Streptomyces sp. SCSIO 11594
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[9] Antimicrobial tunicamycin derivatives from the deep sea-derived Streptomyces xinghaiensis SCSIO S15077
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[10] Complete genome sequence of the deep South China Sea-derived Streptomyces niveus SCSIO 3406, the producer of cytotoxic and antibacterial marfuraquinocins
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