Insulin-Like Growth Factor-1 and Insulin Inhibit Caspase-3/7 Activation Initiated by Interleukin-1β in the Rat Eye Retinal Neurons

被引：0
|
作者：
S. S. Shushanov
机构：
[1] Institute of Carcinogenesis,
[2] N. N. Blokhin Cancer Research Center,undefined
[3] Russian Academy of Medical Sciences,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2010年 / 150卷
关键词：
insulin-like growth factor-1; interleukin-1β; tumor necrosis factor-α; diabetic retinopathy; caspase-3/7;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Proinflammatory cytokine IL-1β specifically stimulates caspase-3/7 in vitro in RGC-5 rat eye retinal neurons. Insulin and insulin-like growth factor-1 and their combination inhibit caspase-3/7 activation in these cells, induced by removal of the serum from culture medium and/or by IL-1β treatment.
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页码：42 / 44
页数：2
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