Elevated level of mitochondrial reactive oxygen species via fatty acid β-oxidation in cancer stem cells promotes cancer metastasis by inducing epithelial–mesenchymal transition

被引：0
|
作者：
Caihua Wang
Liming Shao
Chi Pan
Jun Ye
Zonghui Ding
Jia Wu
Qin Du
Yuezhong Ren
Chunpeng Zhu
机构：
[1] The Second Affiliated Hospital,Department of Gastroenterology
[2] ZhejiangUniversity School of Medicine,Department of Surgical Oncology
[3] The Second Affiliated Hospital,Department of Endocrinology and Metabolism
[4] Zhejiang University School of Medicine,undefined
[5] Department of Biochemistry and Molecular Biology,undefined
[6] Mayo Clinic,undefined
[7] The Second Affiliated Hospital,undefined
[8] Zhejiang University School of Medicine,undefined
来源：
Stem Cell Research & Therapy | / 10卷
关键词：
Cancer stem cells; Tumor sphere; ROS; Cancer metastasis; Mitochondria; Epithelial-mesenchymal transition;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [31] Downregulation of SHMT2 promotes the prostate cancer proliferation and metastasis by inducing epithelial-mesenchymal transition
    Lei Chen
    Liu, Hailong
    Ji, Yiyi
    Ma, Zehua
    Kai Shen
    Xun Shangguan
    Qian, Hongyang
    Yu Zhao
    Pan, Chun-Wu
    Wei Xue
    EXPERIMENTAL CELL RESEARCH, 2022, 415 (02)
  • [32] Downregulation of CHIP promotes ovarian cancer metastasis by inducing Snail-mediated epithelial-mesenchymal transition
    Park, Sun-Mi
    Park, Seung-Ho
    Ryu, Ki-Jun
    Kim, In-Kyu
    Han, Hyeontak
    Kim, Hyo-Jin
    Kim, Seon-Hee
    Hong, Keun-Seok
    Kim, Hyemin
    Kim, Minju
    Cho, Bok Im
    Heo, Jeong Doo
    Kim, Na Hyun
    Hwang, Eun Mi
    Park, Jae-Yong
    Yook, Jong In
    Cho, Hee Jun
    Hwangbo, Cheol
    Kim, Kwang Dong
    Song, Hoseok
    Yoo, Jiyun
    MOLECULAR ONCOLOGY, 2019, 13 (05) : 1280 - 1295
  • [33] ZEB2 Promotes the Metastasis of Gastric Cancer and Modulates Epithelial Mesenchymal Transition of Gastric Cancer Cells
    Dai, Ying-Huan
    Tang, Ya-Ping
    Zhu, Hong-Yi
    Lv, Liang
    Chu, Yi
    Zhou, Yu-Qian
    Huo, Ji-Rong
    DIGESTIVE DISEASES AND SCIENCES, 2012, 57 (05) : 1253 - 1260
  • [34] Low glucose induces mitochondrial reactive oxygen species via fatty acid oxidation in bovine aortic endothelial cells
    Kajihara, Nobuhiro
    Kukidome, Daisuke
    Sada, Kiminori
    Motoshima, Hiroyuki
    Furukawa, Noboru
    Matsumura, Takeshi
    Nishikawa, Takeshi
    Araki, Eiichi
    JOURNAL OF DIABETES INVESTIGATION, 2017, 8 (06): : 750 - 761
  • [35] AURKA promotes cancer metastasis by regulating epithelial-mesenchymal transition and cancer stem cell properties in hepatocellular carcinoma
    Chen, Chenlin
    Song, Guangyuan
    Xiang, Jue
    Zhang, Hongcheng
    Zhao, Shaoyun
    Zhan, Yinchu
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 486 (02) : 514 - 520
  • [36] 12-Lipoxygenase promotes invasion and metastasis of human gastric cancer cells via epithelial-mesenchymal transition
    Zhong, Canmei
    Zhuang, Mingkai
    Wang, Xiazhong
    Li, Jianying
    Chen, Zhixin
    Huang, Yuehong
    Chen, Fenglin
    ONCOLOGY LETTERS, 2018, 16 (02) : 1455 - 1462
  • [37] Coexpression of growth differentiation factor 11 and reactive oxygen species in metastatic oral cancer and its role in inducing the epithelial to mesenchymal transition
    Qin, Xiangming
    Kuang, Hai
    Chen, Lei
    Wei, Shanliang
    Yu, Dahai
    Liang, Feixin
    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, 2017, 123 (06): : 697 - 706
  • [38] KRAS activation in gastric adenocarcinoma stimulates epithelial-to-mesenchymal transition to cancer stem-like cells and promotes metastasis
    Yoon, Changhwan
    Till, Jacob
    Cho, Soo-Jeong
    Chang, Kevin
    Lin, Jian-Xian
    Ryeom, Sandra
    Yoon, Sam
    CANCER RESEARCH, 2019, 79 (13)
  • [39] KRAS Activation in Gastric Adenocarcinoma Stimulates Epithelial-to-Mesenchymal Transition to Cancer Stem-Like Cells and Promotes Metastasis
    Yoon, Changhwan
    Till, Jacob
    Cho, Soo-Jeong
    Chang, Kevin K.
    Lin, Jian-xian
    Huang, Chang-ming
    Ryeom, Sandra
    Yoon, Sam S.
    MOLECULAR CANCER RESEARCH, 2019, 17 (09) : 1945 - 1957
  • [40] Fatty Acid Synthase Mediates the Epithelial-Mesenchymal Transition of Breast Cancer Cells
    Li, Junqin
    Dong, Lihua
    Wei, Dapeng
    Wang, Xiaodong
    Zhang, Shuo
    Li, Hua
    INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2014, 10 (02): : 171 - 180
12345