Integration of Placental Transfer in a Fetal–Maternal Physiologically Based Pharmacokinetic Model to Characterize Acetaminophen Exposure and Metabolic Clearance in the Fetus

被引：0
|
作者：
Paola Mian
Karel Allegaert
Sigrid Conings
Pieter Annaert
Dick Tibboel
Marc Pfister
Kristel van Calsteren
John N. van den Anker
André Dallmann
机构：
[1] Erasmus MC-Sophia Children’s Hospital,Intensive Care and Department of Paediatric Surgery
[2] Pediatric Pharmacology,Department of Clinical Pharmacy
[3] Pharmacometrics Research Center and University Children’s Hospital Basel (UKBB),Department of Development and Regeneration
[4] Medisch Spectrum Twente,Department of Pharmaceutical and Pharmacological Sciences
[5] KU Leuven,Department of Clinical Pharmacy
[6] KU Leuven,Drug Delivery and Disposition Lab, Department of Pharmaceutical and Pharmacological Sciences
[7] Erasmus MC,Department of Obstetrics and Gynecology
[8] KU Leuven,Division of Clinical Pharmacology
[9] University Hospitals Leuven,undefined
[10] Children’s National Hospital,undefined
来源：
Clinical Pharmacokinetics | 2020年 / 59卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：911 / 925
页数：14
相关论文
共 39 条
  • [21] Prediction of Maternal and Fetal Doravirine Exposure by Integrating Physiologically Based Pharmacokinetic Modeling and Human Placenta Perfusion Experiments
    V. E. Bukkems
    H. van Hove
    D. Roelofsen
    J. J. M. Freriksen
    E. W. J. van Ewijk-Beneken Kolmer
    D. M. Burger
    J. van Drongelen
    E. M. Svensson
    R. Greupink
    A. Colbers
    Clinical Pharmacokinetics, 2022, 61 : 1129 - 1141
  • [22] Prediction of Maternal and Fetal Doravirine Exposure by Integrating Physiologically Based Pharmacokinetic Modeling and Human Placenta Perfusion Experiments
    Bukkems, V. E.
    van Hove, H.
    Roelofsen, D.
    Freriksen, J. J. M.
    Kolmer, E. W. J. Van Ewijk-Beneken
    Burger, D. M.
    van Drongelen, J.
    Svensson, E. M.
    Greupink, R.
    Colbers, A.
    CLINICAL PHARMACOKINETICS, 2022, 61 (08) : 1129 - 1141
  • [23] Mechanistic Coupling of a Novel in silico Cotyledon Perfusion Model and a Physiologically Based Pharmacokinetic Model to Predict Fetal Acetaminophen Pharmacokinetics at Delivery
    Mian, Paola
    Nolan, Bridget
    van den Anker, John N.
    van Calsteren, Kristel
    Allegaert, Karel
    Lakhi, Nisha
    Dallmann, Andre
    FRONTIERS IN PEDIATRICS, 2021, 9
  • [24] Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model I: Insights into Factors that Determine Fetal Drug Exposure through Simulations and Sensitivity Analysess
    Zhang, Zufei
    Imperial, Marjorie Z.
    Patilea-Vrana, Gabriela I.
    Wedagedera, Janak
    Lu Gaohua
    Unadkat, Jashvant D.
    DRUG METABOLISM AND DISPOSITION, 2017, 45 (08) : 920 - 938
  • [25] Quantification of sertraline maternal/fetal ratio and amniotic fluid concentration using a pregnancy physiologically based pharmacokinetic model
    Lartey, David
    Jateng, Danielle
    Li, Miao
    Nguyen, Christine
    Crentsil, Victor
    Beitz, Julie
    George, Blessy
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2023,
  • [26] A Physiologically Based Pharmacokinetic Model to Predict the Impact of Metabolic Changes Associated with Metabolic Associated Fatty Liver Disease on Drug Exposure
    Newman, Elise M.
    Rowland, Andrew
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (19)
  • [27] Evaluation of placental and lactational pharmacokinetics of PFOA and PFOS in the pregnant, lactating, fetal and neonatal rat using a physiologically based pharmacokinetic model
    Loccisano, Anne E.
    Campbell, Jerry L., Jr.
    Butenhoff, John L.
    Andersen, Melvin E.
    Clewell, Harvey J., III
    REPRODUCTIVE TOXICOLOGY, 2012, 33 (04) : 468 - 490
  • [28] Development of a physiologically based toxicokinetic model for lead in pregnant women: The role of bone tissue in the maternal and fetal internal exposure
    Daoud, Yourdasmine Ali
    Tebby, Cleo
    Beaudouin, Remy
    Brochot, Celine
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2023, 476
  • [29] Application of a physiologically based pharmacokinetic model to estimate the bioavailability of ethanol in male rats: Distinction between gastric and hepatic pathways of metabolic clearance
    Pastino, GM
    Conolly, RB
    TOXICOLOGICAL SCIENCES, 2000, 55 (02) : 256 - 265
  • [30] A Physiologically-Based Pharmacokinetic Model to Predict Human Fetal Exposure for a Drug Metabolized by Several CYP450 Pathways
    Mendes, Mailys De Sousa
    Lui, Gabrielle
    Zheng, Yi
    Pressiat, Claire
    Hirt, Deborah
    Valade, Elodie
    Bouazza, Naim
    Foissac, Frantz
    Blanche, Stephane
    Treluyer, Jean-Marc
    Urien, Saik
    Benaboud, Sihem
    CLINICAL PHARMACOKINETICS, 2017, 56 (05) : 537 - 550
1234