Integration of Placental Transfer in a Fetal–Maternal Physiologically Based Pharmacokinetic Model to Characterize Acetaminophen Exposure and Metabolic Clearance in the Fetus

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作者
Paola Mian
Karel Allegaert
Sigrid Conings
Pieter Annaert
Dick Tibboel
Marc Pfister
Kristel van Calsteren
John N. van den Anker
André Dallmann
机构
[1] Erasmus MC-Sophia Children’s Hospital,Intensive Care and Department of Paediatric Surgery
[2] Pediatric Pharmacology,Department of Clinical Pharmacy
[3] Pharmacometrics Research Center and University Children’s Hospital Basel (UKBB),Department of Development and Regeneration
[4] Medisch Spectrum Twente,Department of Pharmaceutical and Pharmacological Sciences
[5] KU Leuven,Department of Clinical Pharmacy
[6] KU Leuven,Drug Delivery and Disposition Lab, Department of Pharmaceutical and Pharmacological Sciences
[7] Erasmus MC,Department of Obstetrics and Gynecology
[8] KU Leuven,Division of Clinical Pharmacology
[9] University Hospitals Leuven,undefined
[10] Children’s National Hospital,undefined
来源
Clinical Pharmacokinetics | 2020年 / 59卷
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页码:911 / 925
页数:14
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