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Yonsei Univ, Coll Life Sci & Biotechnol, Yonsei Biomed Sci & Technol Initiat, Chem Genom Lab,Dept Biotechnol, Seoul 120749, South Korea Yonsei Univ, Coll Life Sci & Biotechnol, Yonsei Biomed Sci & Technol Initiat, Chem Genom Lab,Dept Biotechnol, Seoul 120749, South Korea