Signaling pathway switch in breast cancer

被引：0

作者：

Arnaud Guille

Max Chaffanet

Daniel Birnbaum

机构：

[1] Aix-Marseille Université,Centre de Recherche en Cancérologie de Marseille, Oncologie Moléculaire, “Equipe labellisée Ligue Contre le Cancer”, UMR1068 Inserm, CNRS UMR7258, Institut Paoli

来源：

Cancer Cell International | / 13卷

关键词：

Next generation sequencing; Breast cancer; Signaling pathways; Cell cycle; Kinases;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Next generation sequencing studies have drawn the general landscape of breast cancers and identified hundreds of new, actual therapeutic targets. Two major signaling pathways seem to be altered in a vast proportion of breast cancers. The PI3 kinase/AKT pathway is activated and the JUN/MAPK pathway is repressed. Via the regulation of the cell cycle this metabolic switch impacts on the balance between self-renewal, proliferation and differentiation of the tumor-initiating cells

引用

共 50 条

[11] TGF-β Signaling Pathway and Breast Cancer Susceptibility
Scollen, Serena
Luccarini, Craig
Baynes, Caroline
Driver, Kristy
Humphreys, Manjeet K.
Garcia-Closas, Montserrat
Figueroa, Jonine
Lissowska, Jolanta
Pharoah, Paul D.
Easton, Douglas F.
Hesketh, Robin
Metcalfe, James C.
Dunning, Alison M.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2011, 20 (06) : 1112 - 1119
[12] The Hedgehog Signaling Pathway: A Viable Target in Breast Cancer?
Bhateja, Priyanka
Cherian, Mathew
Majumder, Sarmila
Ramaswamy, Bhuvaneswari
CANCERS, 2019, 11 (08)
[13] The cGMP signaling pathway in breast cancer cell lines
Barresi, Mariagiovanna
Roessing, Malte
Menges, Rahel
Stehle, Daniel
Feil, Robert
JOURNAL OF TRANSLATIONAL MEDICINE, 2023, 21 (SUPPL 1)
[14] Estrogen signaling pathway and its imaging in human breast cancer
Hayashi, Shin-ichi
Niwa, Toshifumi
Yamaguchi, Yuri
CANCER SCIENCE, 2009, 100 (10) : 1773 - 1778
[15] The PPAR signaling pathway as a potential biomarker for the diagnosis of breast cancer
Wang, Hengyu
Yang, Yuqin
Luo, Qing
Liu, Minfeng
Luo, Can
Dong, Jianyu
Guo, Jingyun
Ye, Changsheng
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2019, 12 (06): : 7327 - 7336
[16] INSULIN SIGNALING PATHWAY AND BREAST-CANCER - INVITRO MODELS
BELFIORE, A
GIORGINO, F
MADDUX, B
CATALFAMO, R
GIUFFRIDA, D
BREAST CANCER RESEARCH AND TREATMENT, 1992, 22 (02) : 167 - 168
[17] Hedgehog signaling pathway promotes breast cancer adaptation to hypoxia
Lama-Sherpa, Tshering D.
Kammerud, Sarah C.
Shevde, Lalita A.
CANCER RESEARCH, 2020, 80 (16)
[18] Role of STAT3 signaling pathway in breast cancer
Ma, Jia-hui
Qin, Li
Li, Xia
CELL COMMUNICATION AND SIGNALING, 2020, 18 (01)
[19] Notch signaling in breast cancer: From pathway analysis to therapy
Krishna, B. Madhu
Jana, Samir
Singhal, Jyotsana
Horne, David
Awasthi, Sanjay
Salgia, Ravi
Singhal, Sharad S.
CANCER LETTERS, 2019, 461 : 123 - 131
[20] Role of STAT3 signaling pathway in breast cancer
Jia-hui Ma
Li Qin
Xia Li
Cell Communication and Signaling, 18

← 1 2 3 4 5 →