Safety and Pharmacokinetics of HRS-2261, a P2X3 Receptor Antagonist, in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Phase 1 Study

被引：0
|
作者：
Yuru Fan
Xuan Zhang
Qin Zhang
Liang Zheng
Renpeng Zhou
Cheng Sun
Xihan Wang
Ke Song
Zhusheng He
Honghui Wang
Qian Zhang
Wei Hu
机构：
[1] The Second Affiliated Hospital of Anhui Medical University,Department of Clinical Pharmacology
[2] Jiangsu Hengrui Pharmaceuticals Co.,undefined
[3] Ltd,undefined
来源：
Clinical Pharmacokinetics | 2024年 / 63卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：293 / 302
页数：9
相关论文
共 50 条
  • [21] Safety, Tolerability and Pharmacokinetics of Dalcetrapib Following Single and Multiple Ascending Doses in Healthy Subjects A Randomized, Double-Blind, Placebo-Controlled, Phase I Study
    Derks, Michael
    Anzures-Cabrera, Judith
    Turnbull, Lynn
    Phelan, Mary
    CLINICAL DRUG INVESTIGATION, 2011, 31 (05) : 325 - 335
  • [22] A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase 2b Trial of P2X3 Receptor Antagonist Sivopixant for Refractory or Unexplained Chronic Cough
    Lorcan McGarvey
    Jaclyn A. Smith
    Alyn Morice
    Surinder S. Birring
    Kian Fan Chung
    Peter V. Dicpinigaitis
    Akio Niimi
    Michael S. Benninger
    Mandel Sher
    Yuko Matsunaga
    Sayaka Miyazaki
    Mitsuaki Machida
    Hiroyuki Ishihara
    Adnan Mahmood
    Juan-Carlos Gomez
    Lung, 2023, 201 : 25 - 35
  • [23] Safety and tolerability of Ganoderma lucidum in healthy subjects:: A double-blind randomized placebo-controlled trial
    Wicks, Sheila M.
    Tong, Robin
    Wang, Chong-Zhi
    O'Connor, Michael
    Karrison, Theodore
    Li, Shang
    Moss, Jonathan
    Yuan, Chun-Su
    AMERICAN JOURNAL OF CHINESE MEDICINE, 2007, 35 (03): : 407 - 414
  • [24] A Randomized, Double-Blind, Placebo-Controlled, Multiple Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of ELX-02 in Healthy Subjects
    Leubitz, Andi
    Vanhoutte, Frederic
    Hu, Ming-yi
    Porter, Kaela
    Gordon, Efrat
    Tencer, Kathleen
    Campbell, Kathleen
    Banks, Kate
    Haverty, Tom
    CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2021, 10 (08): : 859 - 869
  • [25] Safety and immunogenicity of pentavalent rotavirus vaccine in a randomized, double-blind, placebo-controlled study in healthy elderly subjects
    Lawrence, Jody
    He, Su
    Martin, Jason
    Schoedel, Florian
    Ciarlet, Max
    Murray, Alexander V.
    HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2014, 10 (08) : 2247 - 2254
  • [26] Phase I, double-blind, placebo-controlled study in healthy male subjects to investigate the safety, tolerability, and pharmacokinetics of DA-8159
    Padma-Nathan, H
    Pacik, JS
    Ahn, BO
    Kang, KK
    Bahng, MY
    Kim, WB
    JOURNAL OF UROLOGY, 2004, 171 (04): : 234 - 234
  • [27] AMAGINE-1: a phase 3, randomized, double-blind, placebo-controlled study of brodalumab in subjects with psoriasis
    Papp, K.
    Reich, K.
    Leonardi, C.
    Paul, C.
    Blauvelt, A.
    Baran, W.
    Bolduc, C.
    Toth, D.
    Langley, R. G.
    Cather, J.
    Gottlieb, A. B.
    Thaci, D.
    Milmont, C. E.
    Li, J.
    Klekotka, P.
    Kricorian, G.
    Nirula, A.
    BRITISH JOURNAL OF DERMATOLOGY, 2014, 171 (06) : E119 - E120
  • [28] PHARMACOKINETICS OF LACOSAMIDE IN KOREAN HEALTHY SUBJECTS: A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, SINGLE AND REPEATED DOSE STUDY.
    Gu, N.
    Kim, B. H.
    Lee, S.
    Kim, T. E.
    Fichtner, A.
    Elshoff, J.
    Yu, K. S.
    King, I. J.
    Shin, S. G.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2012, 91 : S84 - S85
  • [29] Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Alirocumab in Healthy Chinese Subjects: A Randomized, Double-Blind, Placebo-Controlled, Ascending Single-Dose Study
    Haiyan Li
    Yudong Wei
    Zhenhua Yang
    Shuang Zhang
    Xiuxiu Xu
    Mengmeng Shuai
    Olivier Vitse
    Yiwen Wu
    Marie T. Baccara-Dinet
    Yi Zhang
    Jianyong Li
    American Journal of Cardiovascular Drugs, 2020, 20 : 489 - 503
  • [30] Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Alirocumab in Healthy Chinese Subjects: A Randomized, Double-Blind, Placebo-Controlled, Ascending Single-Dose Study
    Li, Haiyan
    Wei, Yudong
    Yang, Zhenhua
    Zhang, Shuang
    Xu, Xiuxiu
    Shuai, Mengmeng
    Vitse, Olivier
    Wu, Yiwen
    Baccara-Dinet, Marie T.
    Zhang, Yi
    Li, Jianyong
    AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS, 2020, 20 (05) : 489 - 503
12345