Molecular Markers and Chemotherapy for Advanced Salivary Cancer

被引：11
|
作者：
Vander Poorten V. [1 ,2 ,3 ,6 ]
Meulemans J. [1 ]
Delaere P. [1 ,2 ]
Nuyts S. [2 ,4 ,6 ]
Clement P. [2 ,5 ,6 ]
机构：
[1] Otorhinolaryngology-Head and Neck Surgery, University Hospitals Leuven, Herestraat 49, Leuven
[2] Leuven Cancer Institute, University Hospitals Leuven, Herestraat 49, Leuven
[3] European Salivary Gland Society, Geneva
[4] Radiation Oncology, University Hospitals Leuven, Herestraat 49, Leuven
[5] Medical Oncology, University Hospitals Leuven, Herestraat 49, Leuven
[6] Section Head and Neck Oncology, Department of Oncology, KULeuven, Herestraat 49, Leuven
来源：
Current Otorhinolaryngology Reports | 2014年 / 2卷 / 2期
关键词：
Chemotherapy; Molecular biology; Molecular markers; Salivary gland cancer; Salivary gland neoplasms; Targeted therapy;
D O I：
10.1007/s40136-014-0040-2
中图分类号：
学科分类号：
摘要：
Recent advances in our understanding of the molecular biology of salivary gland neoplasms have yielded diagnostic targets and potential therapeutic targets that have started to change our approach and choice of treatment strategies. Currently, these options are mainly investigated in recurrent and metastatic salivary gland cancer (SGC). Although the results of both cytotoxic and targeted molecular biological systemic therapy for locoregional recurrence and distant spread of SGC remain largely unpredictable, targeted therapy can be the treatment of choice in selected cases today. Molecular analysis is required as part of the diagnostic workup to help select patients with recurrent and metastatic SGC who may benefit from targeted or standard treatment regimens. © 2014, Springer Science+Business Media New York.
引用
收藏
页码：85 / 96
页数：11
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