Stripping voltammetric determination of nicardipine using β-cyclodextrin incorporated carbon nanotube-modified glassy carbon electrode

An electrochemical sensor modified with multi-walled carbon nanotubes-β-cyclodextrin (MWCNTs-β-CD) film was constructed and applied to the determination of nicardipine. The electrochemical behavior of nicardipine at the chemically modified electrode was investigated. After stripping of nicardipine on MWCNTs-β-CD film at −0.9 V for 1 min, a well defined oxidation peak was produced in 0.04 M NaOH. Determination of nicardipine has been further improved by the formation of inclusion complex of β-CD with nicardipine. The MWCNTs-β-CD film showed preferable analytical characteristics in electrocatalytic oxidation for nicardipine compared with the MWCNTs film and bare glassy carbon electrode (GCE). The surface morphology of MWCNTs-β-CD film was characterized by using electrochemical impedance spectroscopy. The calibration curve was linear from 1.0 × 10−7 to 2.0 × 10−5 M. The limit of detection was obtained as 1 × 10−8 M. The results demonstrated that this electrochemical sensor has excellent sensitivity and selectivity. The sensor was applied for determination of nicardipine in blood serum with excellent recoveries.