Updates in IDH-Wildtype Glioblastoma

被引:0
|
作者
Jawad M. Melhem
Jay Detsky
Mary Jane Lim-Fat
James R. Perry
机构
[1] Sunnybrook Health Sciences Centre,Division of Neurology, Department of Medicine, Faculty of Medicine
[2] University of Toronto,Department of Radiation Oncology
[3] Odette Cancer Centre,undefined
[4] Sunnybrook Health Sciences Centre,undefined
来源
Neurotherapeutics | 2022年 / 19卷
关键词
Glioblastoma; IDH-wildtype; Targeted therapy; Precision medicine; Clinical trials;
D O I
暂无
中图分类号
学科分类号
摘要
Glioblastoma is the most aggressive primary brain tumor with a poor prognosis. The 2021 WHO CNS5 classification has further stressed the importance of molecular signatures in diagnosis although therapeutic breakthroughs are still lacking. In this review article, updates on the current and novel therapies in IDH-wildtype GBM will be discussed.
引用
收藏
页码:1705 / 1723
页数:18
相关论文
共 50 条
  • [31] PROGNOSTIC IMPACT OF TUMOR MUTATIONAL BURDEN AT BASELINE IN IDH-WILDTYPE GLIOBLASTOMA
    Park, Dohoon
    Park, Hwan
    Kim, Yongjae
    Park, Kang-Seo
    Park, Ji Eun
    Sung, Chang Ohk
    Yoon, Shinkyo
    Lee, Ho-Su
    NEURO-ONCOLOGY, 2023, 25
  • [32] Radiomics-based prediction of lymphocyte infiltration in IDH-wildtype glioblastoma
    Mair, M. J.
    Leitner, J.
    Zvonek, M.
    Windhager, H.
    Haeller, K.
    Kuehrer, G. J.
    Paiato, C.
    Kiesel, B.
    Woehrer, A.
    Widhalm, G.
    Nenning, K-H.
    Langs, G.
    Preusser, M.
    Furtner, J.
    Berghoff, A. S. S.
    ANNALS OF ONCOLOGY, 2022, 33 (07) : S670 - S670
  • [33] GENOMIC PREDICTORS OF ADVERSE EVENTS IN NEWLY DIAGNOSED IDH-WILDTYPE GLIOBLASTOMA
    Lim-Fat, Mary Jane
    Rahman, Rifaquat
    Muzikansky, Alona
    Woodward, Eleanor
    Whorral, Sydney
    Allen, Marie
    Touat, Mehdi
    Iorgulescu, Bryan
    Youssef, Gilbert
    Chukwueke, Ugonma
    Mcfaline-Figueroa, Jose
    Nayak, Lakshmi
    Lee, Eudocia
    Reardon, David
    Huang, Raymond
    Beroukhim, Rameen
    Bi, Wenya Linda
    Ligon, Keith
    Wen, Patrick
    NEURO-ONCOLOGY, 2020, 22 : 11 - 11
  • [34] Gene Expression Profiling Stratifies IDH-Wildtype Glioblastoma With Distinct Prognoses
    Liu, Yu-Qing
    Wu, Fan
    Li, Jing-Jun
    Li, Yang-Fang
    Liu, Xing
    Wang, Zheng
    Chai, Rui-Chao
    FRONTIERS IN ONCOLOGY, 2019, 9
  • [35] SECONDARY GLIOBLASTOMA, IDH-WILDTYPE ARISING IN DIFFUSE ASTROCYTOMA, IDH-MUTANT: A CASE REPORT
    Lee, Kyu Sang
    Choe, Gheeyoung
    NEURO-ONCOLOGY, 2019, 21 : 99 - 99
  • [36] IDH-wildtype secondary glioblastoma arising in IDH-mutant diffuse astrocytoma: a case report
    Yoon, Byul-Hee
    Park, Ju Sang
    Kang, Seongmin
    Kwon, Nak-Jung
    Lee, Kyu Sang
    Kim, Chae-Yong
    Choe, Gheeyoung
    BRITISH JOURNAL OF NEUROSURGERY, 2023, 37 (05) : 1233 - 1236
  • [37] Is surgical resection predict overall survival in frail patients with glioblastoma, IDH-wildtype?
    Elia, A.
    Bertuccio, A.
    Vitali, M.
    Barbaner, A.
    Pallud, J.
    NEUROCHIRURGIE, 2023, 69 (02)
  • [38] Glioblastoma, IDH-Wildtype With Epithelioid Morphology and a BCR::NTRK2 Fusion
    Umeres-Francia, Gianfranco E.
    Arias-Stella, Javier A.
    Manoukian, Saro
    Arvanitis, Leonidas
    INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 2025, 33 (01) : 138 - 144
  • [39] DISTINCT AGE-RELATED MOLECULAR AND CLINICAL FEATURES IN IDH-WILDTYPE GLIOBLASTOMA
    Richter, S.
    Stasik, S.
    Schackert, G.
    Thiede, C.
    Krex, D.
    Juratli, T. A.
    NEURO-ONCOLOGY, 2022, 24
  • [40] Riskformer: Survival prediction from MR imaging in patients with IDH-wildtype glioblastoma
    You, Huixia
    Zhang, Jiankai
    Zhao, Yuanshen
    Mo, Tong
    Fang, Diangang
    Lv, Xiaofei
    Li, Zhi-Cheng
    Wang, Haifeng
    Liang, Dong
    Zeng, Hongwu
    Chen, Yinsheng
    DISPLAYS, 2023, 79