Interrelationship Between Substrates and Inhibitors of Human CYP3A and P-Glycoprotein

被引：0

作者：

Richard B. Kirn

Christoph Wandel

Brenda Leake

Mirjana Cvetkovic

Martin F. Fromm

Peter J. Dempsey

Mark M. Roden

Frank Belas

Ajai K. Chaudhary

Dan M. Roden

Alastair J. J. Wood

Grant R. Wilkinson

机构：

[1] Vanderbilt University School of Medicine,Departments of Medicine and Pharmacology

来源：

Pharmaceutical Research | 1999年 / 16卷 / 3期

关键词：

CYP3A4; P-glycoprotein; drug transport; cytochrome P450;

D O I：

10.1023/A:1018877803319

中图分类号：

学科分类号：

摘要：

Purpose. CYP3A and P-gp both function to reduce the intracellular concentration of drug substrates, one by metabolism and the other by transmembrane efflux. Moreover, it has been serendipitously noted that the two proteins have many common substrates and inhibitors. In order to test this notion more fully, systematic studies were undertaken to determine the P-gp-mediated transport and inhibitory characteristics of prototypical CYP substrates.

引用

页码：408 / 414

页数：6

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