Interrelationship Between Substrates and Inhibitors of Human CYP3A and P-Glycoprotein

被引：0
|
作者：
Richard B. Kirn
Christoph Wandel
Brenda Leake
Mirjana Cvetkovic
Martin F. Fromm
Peter J. Dempsey
Mark M. Roden
Frank Belas
Ajai K. Chaudhary
Dan M. Roden
Alastair J. J. Wood
Grant R. Wilkinson
机构：
[1] Vanderbilt University School of Medicine,Departments of Medicine and Pharmacology
来源：
Pharmaceutical Research | 1999年 / 16卷 / 3期
关键词：
CYP3A4; P-glycoprotein; drug transport; cytochrome P450;
D O I：
10.1023/A:1018877803319
中图分类号：
学科分类号：
摘要：
Purpose. CYP3A and P-gp both function to reduce the intracellular concentration of drug substrates, one by metabolism and the other by transmembrane efflux. Moreover, it has been serendipitously noted that the two proteins have many common substrates and inhibitors. In order to test this notion more fully, systematic studies were undertaken to determine the P-gp-mediated transport and inhibitory characteristics of prototypical CYP substrates.
引用
收藏
页码：408 / 414
页数：6
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