Ewing’s Sarcoma: Standard and Experimental Treatment Options

被引:0
|
作者
Vivek Subbiah
Pete Anderson
Alexander J. Lazar
Emily Burdett
Kevin Raymond
Joseph A. Ludwig
机构
[1] University of Texas M.D. Anderson Cancer Center,Department of Pediatrics
[2] University of Texas M.D. Anderson Cancer Center,Department of Pathology
[3] Rice University,Division of Bio
[4] M.D. Anderson Cancer Center,Medical Engineering
来源
Current Treatment Options in Oncology | 2009年 / 10卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Ewing sarcoma family tumors (EWS), which include classic Ewing’s sarcoma in addition to primitive neuroectodermal tumor and Askin tumor, are the second most common variety of primary bone cancer to afflict adolescents and young adults. Multi-disciplinary care incorporating advances in diagnosis, surgery, chemotherapy, and radiation has substantially improved the survival rate of patients with localized Ewing sarcoma to nearly 70%. Unfortunately, those advances have not significantly changed the long-term outcome for those with metastatic or recurrent disease; 5-year survival remains less than 25%. This apparent therapeutic plateau exists despite extensive effort during the last four decades to optimize the efficacy of cytotoxic chemotherapy through combination of chemotherapies of mechanistically diverse action, dose-dense scheduling (provided as frequently as every 2 weeks), increased adjuvant treatment duration, and higher dosage per cycle (facilitated with parallel strides in supportive care incorporating growth factors). As has already occurred for malignancies such as breast or colon cancer, the “-omics-based” revolution has enhanced our understanding of the molecular changes responsible for Ewing’s tumor formation and identified a number of potential targets (such as IGF-1R or mTOR) amenable to biological therapy. It has also created both a challenge and an opportunity to develop predictive biomarkers capable of selecting patients most likely to benefit from targeted therapy. In this review, we discuss current standard-of-care for patients with Ewing’s sarcoma and highlight the most promising experimental therapies in early-phase clinical trials.
引用
收藏
页码:126 / 140
页数:14
相关论文
共 50 条
  • [21] Ewing's sarcoma
    Geschickter, CF
    Maseritz, IH
    JOURNAL OF BONE AND JOINT SURGERY, 1939, 21 : 26 - 39
  • [22] Outcome of multimodality treatment of Ewing’s sarcoma of the extremities
    Akshay Tiwari
    Himesh Gupta
    Sandeep Jain
    Gauri Kapoor
    Indian Journal of Orthopaedics, 2010, 44 : 378 - 383
  • [23] Unlocking epigenetics for precision treatment of Ewing's sarcoma
    Fan, Zhehao
    Dong, Shuangshuang
    Wang, Ning
    Khawar, Muhammad Babar
    Wang, Jingcheng
    Sun, Haibo
    CHINESE JOURNAL OF CANCER RESEARCH, 2024, 36 (03)
  • [24] The Treatment Outcome for Adult Patients with Ewing’s Sarcoma
    Kristen N. Ganjoo
    Shreyaskumar Patel
    Current Oncology Reports, 2013, 15 : 372 - 377
  • [25] Combined modality treatment of Ewing's sarcoma of the maxilla
    Wexler, LH
    Kacker, A
    Piro, JD
    Haddad, J
    Close, LG
    HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2003, 25 (02): : 168 - 172
  • [26] Outcome of multimodality treatment of Ewing's sarcoma of the extremities
    Tiwari, Akshay
    Gupta, Himesh
    Jain, Sandeep
    Kapoor, Gauri
    INDIAN JOURNAL OF ORTHOPAEDICS, 2010, 44 (04) : 378 - 383
  • [27] The Treatment Outcome for Adult Patients with Ewing's Sarcoma
    Ganjoo, Kristen N.
    Patel, Shreyaskumar
    CURRENT ONCOLOGY REPORTS, 2013, 15 (04) : 372 - 377
  • [28] Second malignancies after treatment for Ewing's sarcoma
    Ahrens, S
    Dunst, J
    Rube, C
    Paulussen, M
    Hoffmann, C
    Jurgens, H
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1997, 39 (02): : 142 - 142
  • [29] Pathologic fracture as a complication in the treatment of Ewing's sarcoma
    Fuchs, B
    Valenzuela, RG
    Sim, FH
    CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2003, (415) : 25 - 30
  • [30] Treatment of Ewing's sarcoma with two different protocols
    Sokolov, T
    Stoianova, A
    Mumdjiev, I
    Mihova, A
    ANNALES DE MEDECINE INTERNE, 2001, 152 (08): : 497 - 501