Restricting HIV the SAMHD1 way: through nucleotide starvation

被引：0

作者：

Diana Ayinde

Nicoletta Casartelli

Olivier Schwartz

机构：

[1] Diana Ayinde,Département de Virologie

[2] Nicoletta Casartelli and Olivier Schwartz are at the Institut Pasteur,undefined

[3] Unité Virus et Immunité,undefined

[4] Centre National de la Recherche Scientifique,undefined

[5] Unité de Recherche Associée 3015,undefined

[6] 28 rue du Docteur Roux,undefined

[7] F-75015 Paris,undefined

[8] France.,undefined

来源：

Nature Reviews Microbiology | 2012年 / 10卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

SAMHD1 has emerged as a novel HIV restriction factor that inhibits viral replication by limiting dNTP availability. Here, Schwartz and colleagues discuss the studies that led to the identification and characterization of SAMHD1, and speculate on why HIV-1 does not encode the SAMHD1-targeting protein, Vpx.

引用

页码：675 / 680

页数：5

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