Basal ganglia engagement during REM sleep movements in Parkinson’s disease

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作者
Ajay K. Verma
Sergio Francisco Acosta Lenis
Joshua E. Aman
David Escobar Sanabria
Jing Wang
Amy Pearson
Meghan Hill
Remi Patriat
Lauren E. Schrock
Scott E. Cooper
Michael C. Park
Noam Harel
Michael J. Howell
Colum D. MacKinnon
Jerrold L. Vitek
Luke A. Johnson
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[1] University of Minnesota,Department of Neurology
[2] University of Minnesota,Department of Radiology
[3] University of Minnesota,Department of Neurosurgery
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To elucidate the role of the basal ganglia during REM sleep movements in Parkinson’s disease (PD) we recorded pallidal neural activity from four PD patients. Unlike desynchronization commonly observed during wakeful movements, beta oscillations (13–35 Hz) synchronized during REM sleep movements; furthermore, high-frequency oscillations (150–350 Hz) synchronized during movement irrespective of sleep-wake states. Our results demonstrate differential engagement of the basal ganglia during REM sleep and awake movements.
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