Role of 5-HT1A and 5-HT1B Receptors in the Mediation of Behavior in the Forced Swim Test in Mice

被引：0
|
作者：
Michael F O'Neill
Michael W Conway
机构：
[1] Lilly Research Centre,
[2] Eli Lilly & Co,undefined
来源：
Neuropsychopharmacology | 2001年 / 24卷
关键词：
5-HT; receptors; 5-HT; receptors; Anpirtoline; Isamoltane; Forced swim test; Mouse;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The purpose of this study was to further examine the effect of activation of 5-HT1A and 5-HT1B receptors in the forced swim test in mice and to determine if activation of these receptors played a role in the mediation of the effects of the tricyclic antidepressant imipramine. The 5-HT1A agonist 8-OH-DPAT decreased immobility in the forced swim test in mice as previously described. Both the selective 5-HT1B agonist anpirtoline (1.25–5 mg/kg) and mixed 5-HT1A/B agonist RU24969 (0.6–2.5 mg/kg) significantly increased time spent swimming in the FST.
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页码：391 / 398
页数：7
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