Synthesis and Neurotropic Activity of 8-Amino Derivatives of Condensed Thieno[3,2-d]- and Furo[3,2-d]Pyrimidines

被引:0
|
作者
S. N. Sirakanyan
A. A. Ovakimyan
A. S. Noravyan
N. S. Minasyan
I. A. Dzhagatspanyan
I. M. Nazaryan
A. G. Akopyan
机构
[1] National Academy of Sciences of Armenia,Mndjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
[2] National Academy of Sciences of Armenia,Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
来源
关键词
pyrano[3,4-; ]pyridines; thieno[3,2-; ]pyrimidines; furo[3,2-; ]pyrimidines; cyclization; amino derivatives; neurotropic activity;
D O I
暂无
中图分类号
学科分类号
摘要
New derivatives of pyrano[4″,3″:4′,5′]pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines based on 3-chloro derivatives of pyrano[3,4-c]pyridines and pyrano[4″,3″:4′,5′]pyrido[3′,2′:4,5]furo[3,2-d]pyrimidines based on previously prepared 8-chloro derivatives were synthesized. Studies of the biological activity of the synthesized compounds showed that several of them exhibited neurotropic properties.
引用
收藏
页码:655 / 659
页数:4
相关论文
共 50 条
  • [21] Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines
    Temburnikar, Kartik W.
    Zimmermann, Sarah C.
    Kim, Nathaniel T.
    Ross, Christina R.
    Gelbmann, Christopher
    Salomon, Christine E.
    Wilson, Gerald M.
    Balzarini, Jan
    Seley-Radtke, Katherine L.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (07) : 2113 - 2122
  • [22] AMINE DERIVATIVES OF PYRROLO[3,2-D]PYRIMIDINES
    MODNIKOVA, GA
    TITKOVA, RM
    GLUSHKOV, RG
    SOKOLOVA, AS
    SILIN, VA
    CHERNOV, VA
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1988, 22 (02): : 185 - 191
  • [23] ELECTROPHILIC SUBSTITUTION IN THIENO[3,2-D]-PYRAZOLE AND SELENOPHENO[3,2-D]-PYRAZOLE
    KOSHELEV, YN
    REZNICHE.AV
    EFROS, LS
    KVITKO, IY
    ZHURNAL ORGANICHESKOI KHIMII, 1973, 9 (10): : 2201 - 2204
  • [24] An expedient approach for the synthesis of pyrrolo[3,2-d]pyrimidines (9-deazaxanthines) and furo[3,2-d]pyrimidine via radical cyclization
    Majumdar, K. C.
    Mondal, Shovan
    TETRAHEDRON, 2009, 65 (46) : 9604 - 9608
  • [25] New heterocyclic systems: Pyrido[2′,3′:5,4]thieno(furo)[3,2-d]oxazines as intermediate compounds for the synthesis of substituted pyrido[3′,2′:4,5]thieno(furo)[3,2-d]pyrimidines
    Sirakanyan, Samvel N.
    Spinelli, Domenico
    Geronikaki, Athina
    Hakobyan, Elmira K.
    Hovakimyan, Anush A.
    SYNTHETIC COMMUNICATIONS, 2019, 49 (21) : 2823 - 2833
  • [26] THE SYNTHESIS AND TRANSFORMATIONS OF 2-ETHOXYCARBONYL-3-ISOTHIOCYANATOPYRIDINE - PYRIDO[3,2-D]PYRIMIDINES AND SOME AZOLOPYRIDO[3,2-D]PYRIMIDINES
    URLEB, U
    STANOVNIK, B
    TISLER, M
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1990, 27 (02) : 407 - 412
  • [27] TRIALKYLINDOLO [3,2-D]THIAZOLE AND TETRAALKYLINDOLO[3,2-D]THIAZOLE AND THEIR DERIVATIVES
    DZYUBENKO, VG
    ABRAMENKO, PI
    ZHURNAL ORGANICHESKOI KHIMII, 1987, 23 (03): : 631 - 637
  • [28] SYNTHESIS AND CYTOKININ ACTIVITY OF SUBSTITUTED PYRROLO[3,2-D]-PYRIMIDINES
    SUGIYAMA, T
    MATSUBARA, S
    KOBAYASHI, S
    HASHIZUME, T
    AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1977, 41 (03): : 605 - 606
  • [29] Synthesis and in vivo Antihyperlipidemic Potential of Novel Substituted Thieno[3,2-d]pyrimidines
    Tamboli, Riyaj Shaukat
    Amrutkar, Rakesh Devidas
    Jain, Kishor Sanchlal
    Kathiravan, Muthu Kumaradoss
    LETTERS IN DRUG DESIGN & DISCOVERY, 2013, 10 (09) : 906 - 915
  • [30] Synthesis and biological activity of some benzofuro[3,2-d]pyrimidines
    Bodke, Y
    Sangapure, SS
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2003, 80 (03) : 187 - 189