BRCA1 mutations and phenotype

被引：0
|
作者：
K. Grade
K. Höffken
R. Kath
A. Nothnagel
E. Bender
S. Scherneck
机构：
[1] Max-Delbrück-Zentrum für Molekulare Medizin,Forschungsbereich Tumorgenetik
[2] Friedrich-Schiller-Universität Jena,Klinik für Innere Medizin
来源：
Journal of Cancer Research and Clinical Oncology | 1997年 / 123卷
关键词：
Mutations; Phenotype;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
More than 100 mutations have been described for the breast-cancer-susceptibility geneBRCA1. The paper describes phenotypical aspects of three selected mutations located at the beginning, in the middle, and at the end of the gene. A remarkable decrease of the age of diagnosis of the mammary carcinoma is observed with increasing length of the putative gene product, combined with greater severity of the disease.
引用
收藏
页码：69 / 70
页数：1
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