Multiple single-nucleotide polymorphisms (SNPs) in the Japanese population in six candidate genes for long QT syndrome

被引：0

作者：

H. Iwasa

M. Kurabayashi

R. Nagai

Y. Nakamura

T. Tanaka

机构：

[1] Laboratory of Molecular Medicine,

[2] Human Genome Center,undefined

[3] Institute of Medical Science,undefined

[4] University of Tokyo,undefined

[5] 4-6-1 Shirokanedai,undefined

[6] Minato-ku,undefined

[7] Tokyo 108-8639,undefined

[8] Japan Tel. +81-3-5449-5373; Fax +81-3-5449-5406 e-mail: toshitan@ims.u-tokyo.ac.jp,undefined

[9] Second Department of Internal Medicine,undefined

[10] Gunma University School of Medicine,undefined

[11] Gunma,undefined

[12] Japan,undefined

[13] Department of Cardiovascular Medicine,undefined

[14] Graduate School of Medicine,undefined

[15] University of Tokyo,undefined

[16] Tokyo,undefined

[17] Japan,undefined

来源：

Journal of Human Genetics | 2001年 / 46卷

关键词：

Key words Long QT syndrome; Single-nucleotide polymorphism; Japanese population; Cardiac potassium channel; β1-Adrenergic receptor; Vesicular monoamine transporter;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We report here 20 single-nucleotide polymorphisms (SNPs), including 15 novel ones, in six genes that are considered to be candidates for long QT syndrome (LQTS): 2 SNPs in KCNB1, 3 in KCND3, 3 in KCNJ11, 7 in ABCC9, 3 in ADRB1, and 2 in SLC18A2. We also examined their allelic frequencies in a Japanese sample population of LQTS-affected and nonaffected individuals. These data will be useful for genetic association studies designed to investigate acquired arrhythmias.

引用

页码：158 / 162

页数：4

共 50 条

[31] Evaluation of Japanese potatoes using single nucleotide polymorphisms (SNPs)
Toshiya Igarashi
Mutsuo Tsuyama
Keiichi Ogawa
Emiko Koizumi
Rena Sanetomo
Kazuyoshi Hosaka
Molecular Breeding, 2019, 39
[32] Single nucleotide polymorphisms in arrhythmia genes modify the risk of cardiac events and sudden death in long QT syndrome
Earle, Nikki
Han, Dug Yeo
Pilbrow, Anna
Crawford, Jackie
Smith, Warren
Shelling, Andrew N.
Cameron, Vicky
Love, Donald R.
Skinner, Jonathan R.
HEART RHYTHM, 2014, 11 (01) : 76 - 82
[33] Genomic structure and multiple single-nucleotide polymorphisms (SNPs) of the thiopurine S-methyltransferase (TPMT) gene
Toyokazu Seki
Toshihiro Tanaka
Yusuke Nakamura
Journal of Human Genetics, 2000, 45 : 299 - 302
[34] Prognostic value of single nucleotide polymorphisms (SNPs) of candidate genes associated with inflammation in early-stage
Murray, J. L.
Thompson, P.
Zhou, R.
Yoo, S. Y.
Liu, Y.
Do, K.
Sahin, A. A.
Bondy, M.
Brewster, A. M.
JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15)
[35] Genomic structure and multiple single-nucleotide polymorphisms (SNPs) of the thiopurine S-methyltransferase (TPMT) gene
Seki, T
Tanaka, T
Nakamura, Y
JOURNAL OF HUMAN GENETICS, 2000, 45 (05) : 299 - 302
[36] QT Interval Determinant Mutations, Rare Variants, or Single-Nucleotide Polymorphisms?
Aiba, Takeshi
Takahashi, Atsushi
CIRCULATION-CARDIOVASCULAR GENETICS, 2017, 10 (05)
[37] Single-nucleotide polymorphisms (SNPs) in the human dihydrofolate reductase (DHFR) gene among Japanese with leukemias/lymphomas.
Goto, Y
Saikawa, Y
Hashimoto, K
Yue, L
Nishimura, R
Ichihara, T
Koizumi, S
BLOOD, 1999, 94 (10) : 281A - 281A
[38] Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population
Driver, Kristy E.
Song, Honglin
Lesueur, Fabienne
Ahmed, Shahana
Barbosa-Morais, Nuno L.
Tyrer, Jonathan P.
Ponder, Bruce A. J.
Easton, Douglas F.
Pharoah, Paul D. P.
Dunning, Alison M.
CARCINOGENESIS, 2008, 29 (02) : 333 - 341
[39] Association of Single-Nucleotide Polymorphisms in Interleukin Genes with Microbial Keratitis in a South Indian Population
Konda, Nagaraju
Chakrabarti, Subhabrata
Garg, Prashant
Willcox, Mark D. P.
PATHOGENS, 2022, 11 (11):
[40] Single-molecule detection of single-nucleotide polymorphisms (SNPs) in DNA hybridization kinetics
Manhart, Michael
Peterson, Eric
Harris, Joel
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251

← 1 2 3 4 5 →